产前血型抗体与ABO新生儿溶血病的关系分析

Analysis of the relationship between prenatal blood type antibody and ABO in the pathogenesis of hemolytic disease of the newborn

目的研究分析产前血型抗体与ABO新生儿溶血疾病之间关系。方法择取2010年5月-2013年5月期间在我院进行ABO、Rh血型血清学检查的1264对夫妻,对血型不合夫妻中的434例孕妇进行血型Ig G抗体检查,将抗体效价>64作为阳性,并且检测阳性孕妇生产的新生儿是否患有新生儿溶血病。结果夫妻ABO血型不合有430对,约34.02%;Rh不合有4对,约0.32%。434例血型不合孕妇中276例血型Ig G抗体阳性,约63.59%,而276例血型Ig G抗体阳性生产后患有新生儿溶血病者32例,约11.59%。结论孕妇产前血型抗体的效价越高,新生儿患有溶血病的概率越高,二者之间具有正比的相关性。

【Objective】Analysis of relationship between antenatal blood group ABO hemolytic disease and antibody of newborn.【Methods】1264 couples choose 2010.05-2013.05 during ABO, Rh blood group serological examination in our hospital, 434 cases of pregnant women on incompatible couple of blood group Ig G antibody test, the antibody titer of greater than 64 were used as positive, positive pregnant women and newborns whether Huan Youxin begat hemolytic disease.【Results】The couple ABO blood group incompatibility of 430, about 34.02%; Rh is 4, about 0.32%. 434 cases of maternal fetal blood group incompatibility group Ig G antibody positive in 276 cases, about 63.59%, and 276 cases of blood group Ig G antibody positive in 32 cases of hemolytic disease of production after the newborn, is about 11.59%. 【Conclusion】Antenatal blood group antibody titer of pregnant women is higher, the probability of hemolytic disease of newborn with higher correlation, have direct proportion between the two.