PPARγ在妊娠期糖尿病脂肪及胎盘组织的表达及临床意义被引量：1

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摘要目的探讨PPARγ在妊娠期糖尿病脂肪及胎盘组织的表达及临床效果,并分析其应用价值与意义。方法选取我院2014年6-12月期间收治的妊娠期糖尿病患者60例作为试验组,选取60例正常妊娠孕妇作为对照组,检测试验组患者与对照组孕妇组织中的PPARγ mRNA及蛋白质的水平情况,并比较两组研究对象的体质指数、空腹胰岛素及空腹血糖差异。结果从实验数据可得,试验组组织中的PPARγ mRNA及蛋白质的水平情况与对照组的水平含量差异有统计学意义(P<0.05)。试验组的空腹胰岛素以及空腹血糖的水平与对照组相比,差异具有统计学意义(P<0.05)。结论妊娠糖尿病患者胎盘组织中PPARγ的表达容易受到抑制,导致胎盘部分的葡萄糖以及蛋白质代谢发生紊乱,并且影响了胰岛素的敏感性,可能会影响胎儿的生长。

作者潘小佳高宇朱智鹏

机构地区深圳市人民医院产科

出处《中国医学工程》 2015年第7期165-165,167,共2页 China Medical Engineering

基金 2014年深圳市科创委项目(JCYJ20140416122812000)

关键词 PPARΓ 妊娠期糖尿病胎盘组织表达

分类号 R587.1 [医药卫生—内分泌]

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