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联合检测生化标志物在急性冠脉综合症中预后评估分析

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摘要 目的探究联合检测生化标志物在急性冠脉综合症中预后评估分析,主要选择的生化标志物有白介素-6(IL-6)、基质金属蛋白酶-1(MMP-1)、B型尿钠肽(BNP)、超敏C反应蛋白(hs-CRP)及肌钙蛋白I(cTnI)。方法选取2011年2月-2014年10月期间因冠心病入住我院进行治疗的132例患者,按照患者临床表现、心电图状况、心肌酶谱及冠状动脉造影资料,将患者分为4组,主要有稳定性心绞痛组24例、急性心肌梗死(AMI)33例、不稳定型心绞痛(UAP)44例,31例造影检查结果冠正常的患者为对照组。采患者外周静脉血,进行IL-6、MMP-1、BNP、hs-CRP和cTnI水平检测,将各组患者IL-6、MMP-1、BNP、hs-CRP及cTnI水平进行对比,从而为判断急性冠脉综合症预后提供参考。结果在不同类型急性冠脉综合症患者各组与对照组患者进行各项生化指标检测水平对比,差异均有统计学意义(P<0.05);在血清cTnI、IL-6、MMP-1、BNP、hs-CRP在AMI组、SAP组、UAP组进行组间两两比较中,差异均有统计学意义(P<0.05)。结论患者急性冠脉综合征发病后,机体内炎性生化标志物出现高表达,因此在临床上进行生化标志物联合检测,可以进行有效诊断的同时,为判断患者预后效果提供积极参考价值。
出处 《中国医学工程》 2015年第7期192-193,共2页 China Medical Engineering
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