ciRS-7/miR-7轴调控肿瘤生长转移的研究进展

Regulative role of ciRS-7/miR-7 axis in tumor growth and metastasis: recent advances

抑癌因子mi RNA-7(mi R-7)在肿瘤组织发生中表达下降,但机制未明。最近发现环状RNA-7(ci RS-7)具有mi R-7海绵样吸附作用,从而抑制mi R-7的功能,该发现为探索mi R-7在肿瘤中表达降低的原因开辟了新的途径。目前认为ci RS-7/mi R-7轴不仅具有重要的生物学作用,同时参与机体多种疾病的发生发展。笔者就ci RS-7/mi R-7轴调控肿瘤生长转移的研究进展进行综述。

Tumor suppressor miRNA-7 （miR-7） is found down-regulated in cancer tissues, but the underlying mechanism remains elusive. Recent studies demonstrated that circular RNA-7 （ciRS-7） acts as a sponge for miR-7 and thus can inhibit the miRNA-7 activity. This finding provided a new perspective for revealing the mechanisms of decreased expression of miR-7 in tumors. It is now believed that the ciRS-7/miR-7 axis not only has important biological functions, but participates in the occurrence and development of a range of diseases. Here, the authors present the research progress in ciRS-7/miR-7 axis regulating tumor growth and metastasis.