白细胞计数与甲状腺未分化癌预后负相关原因初探

Preliminary Research on Negative Correlation between White Blood Cell Count and Prognosis of Anaplastic Thyroid Cancer

目的探讨甲状腺未分化癌(ATC)患者白细胞(WBC)计数与预后负相关的原因.方法回顾性分析云南省肿瘤医院20 a间收治的42例ATC患者的临床及随访资料,采用免疫组化的方法检测存档ATC蜡块中CSF1、EPO、IL-6和IL-11表达水平,探索其表达水平与ATC患者预后及WBC计数的关系.结果 42例ATC组织中CSF1、EPO、IL-6和IL-11阳性率分别为69.0%、69.0%、83.3%和71.4%;CSF1和IL-11表达水平与ATC患者预后负相关、与WBC计数正相关(P<0.05),而EPO和IL-6与患者预后及WBC计数均无相关性(P>0.05).结论 WBC计数是ATC患者负相关因素,可能与ATC细胞分泌CSF1和IL-11有关,其机制值得进一步深入研究.

Objective To explore the reason of the negative correlation of white blood cell （WBC） count with the prognosis of patients with anapIastic thyroid carcinoma （ATC） . Methods Clinical and follow-up data of 42 ATC patients at our hospital were analyzed retrospectively. The expressions of CSF1, EPO, IL-6 and IL-11 in specimens of these patients were evaluated by immunohistochemistry, and the relationships with the prognosis and WBC count of ATC patients were investigated. Results The positive rates of CSF1, EPO, IL-6 and IL-11 were 69%, 69%, 83.3% and 71.4%, respectively. The expressions of CSF1 and IL-11 were positively correlated to WBC count and negatively correlated to the prognosis of ATC patients, but the expressions of EPO and IL-6 were neither correlated to the prognosis nor to the WBC count. Conclusion The negative correlation between WBC count and the prognosis of ATC patients may be related to the secretions of CSF1 and IL-11 of ATC cells, but its exact mechanism deserved to be researched in the future.