增强型体外反搏治疗慢性心衰的临床疗效观察

Clinical Efficacy of Enhanced External Counterpulsation in Treatment of Chronic Heart Failure

目的探讨增强型体外反搏治疗慢性心衰的临床疗效.方法选择慢性心衰患者106例,随机分为对照组及观察组,分别有53例.对照组采用常规治疗,观察组在此基础上加用增强型体外反搏治疗,分别检测血EDF、CTGF、Np、Hcy及超声心动图.结果对照组及观察组患者EDF、CTGF水平治疗后较治疗前均出现显著性降低(P<0.05),观察组患者治疗后EDF、CTGF较对照组患者均出现显著性下降(P<0.05).观察组患者Np、Hcy水平治疗后较治疗前均出现显著性降低(P<0.05),对照组患者Hcy水平治疗后较治疗前均出现显著性降低(P<0.05),观察组患者治疗后Np、Hcy较对照组患者均出现显著性下降(P<0.05).对照组及观察组患者LVEF、E/E'水平治疗后较治疗前均出现显著性差异(P<0.05),观察组患者治疗后E/E较对照组患者均出现显著性下降(P<0.05).结论增强体外反搏治疗慢性心衰,可通过改善EDF、CTGF、Np、Hcy水平起到改善心功能状态的作用.

Objective To investigate the clinical efficacy of enhanced external counterpulsation （EECP） in the treatment of chronic heart failure. Methods 106 patients with chronic heart failure were randomly and equally divided into a control group and a observation group. Patients in the control group accepted conventional treatment, and patients in the observation group were treated with EECP therapy on this basis. EDF, CTGF, Np, and Hey were detected and echocardiogram was examined. Results In both groups, levels of EDF, CTGF and Hey significantly decreased after treatment （P 〈0.05） . Levels of EDF, CTGF, Np and Hcy in observation group were significantly lower than those in control group （P 〈0.05） . The observation group showed a significant decrease in the level of Np after treatment （P 〈0.05） . There were significant differences in LVEF and E/E＇ levels before and after treatment in both groups （P 〈0.05） , and the level of E/E＇ in the observation group was significantly lower than that in control group （P 〈0.05） . Conclusion EECP treatment of chronic heart failure could improve the levels of EDF, CTGF, Np and Hcy to improving cardiac function.