瘦素及其长受体在胆囊癌中的表达和意义

Expressions and Significance of Leptin and OB-R1 in Gallbladder Carcinoma

目的探讨瘦素及其长受体在胆囊癌中的表达和意义.方法选取昆明医科大学第二附属医院2008年1月至2014年10月收治的胆囊癌病例20例及同期收治的胆囊结石患者20例,应用免疫组化检测20例胆囊癌患者的胆囊癌及癌旁组织(距胆囊癌组织边缘2 cm以上)及20例胆囊结石患者的胆囊壁组织中瘦素及其长受体的表达,图像分析其表达情况及差异.结果胆囊癌组织中瘦素及其长受体的表达显著高于其在癌旁组织及胆囊结石的胆囊壁组织中的表达(P<0.05);癌旁组织及胆囊结石的胆囊壁组织均有瘦素及其长受体表达,但差异无统计学意义(P>0.05).结论瘦素及其长受体与胆囊癌的形成相关,可能成为临床预测胆囊癌的一个指标.

Objective To analyze the expression and significance of leptin and OB-R1 in gallbladder carcinoma. Methods 20 cases of gallbladder carcinoma and 20 patients with cholecystolithiasis were selected who were diagnosed and treated in our hospital from January 2008 to October 2014. The expressions of leptin and OB-R1 in 20 cases of gallbladder carcinoma and the carcinoma adjacent tissue （2 cm away from carcinoma） , and 20 cases of gallbladder wall tissue of cholecystolithiasis were analyzed by immunohistochemistry, respectively. Results The expressions of leptin and OB-R1 in the gallbladder carcinoma group were significantly higher than those in carcinoma adjacent non-infiltrate tissue group and gallbladder wall tissue cholecystolithiasis group （P 〈0.05） The expressions in both carcinoma adjacent non-infiltrate tissue group and gallbladder wall tissue of cholecystolithiasis group were no significant difference in the quantity （P〉0.05） Conclusion Leptin and OB-R1 may play important roles in the pathogenesis of gallbladder carcinoma, and it might be used as indexes of clinical prediction of gallbladder carcinoma.