492例细菌性阴道病患者加德纳菌检测与药敏分析

Bacteria detection and drug sensitivity analysis of Gardnrella vaginallis from 492 bacterial vaginosis patients

目的了解当地女性细菌性阴道病(BV)患者中阴道加德纳菌(GV)的感染情况以及GV对常用抗菌药物的敏感性,为BV的诊断和治疗提供依据。方法对收集的492例BV患者和151例正常健康妇女的阴道分泌物进行GV的分离培养与鉴定,并对分离菌进行常用抗菌药物敏感性试验。结果 492例BV患者GV阳性率为27.8%,健康妇女GV阳性率为7.9%,两者比较差异有统计学意义(P<0.05)。分离的GV对万古霉素和克林霉素均较敏感,对头孢噻肟、四环素、左氧氟沙星、氨苄青霉素、红霉素、甲硝唑的敏感性依次降低。结论 GV为当地BV患者的重要病原菌之一,且对万古霉素和克林霉素均较敏感,对甲硝唑的敏感性最低。

Objective To understand the infection status of Gardnrella vaginallis（ GV） in female,and to keep abreast of the sensitivity of GV to antibiotics in common use,to provide the scientific basis for clinical diagnosis and treatment.Methods 492 vaginal secretion samples and 151 samples were collected from bacterial vaginosis（ BV） patients and healthy female adults respectively,and then GV were isolated and characterized. The bacterial antibiotic sensitivities were detected. Results The positive rate of 492 cases of BV patients is 27. 8%,and the positive rate of control woman is 7. 9%（ P〈0. 001）. The difference between two groups is of the statistical significance. The isolated GV strains are sensitive to vancomycin and clindamycin with higher level. In regular sequence of antibiotic sensitivities from high to low is cefotaxime,tetracycline,levofloxacin,ampicillin,erythromycin and metronidazole. Conclusion GV is one of important pathogens of BV,and it is higher sensitive to vancomycin and clindamycin,and it is the lowest sensitive to metronidazole.