补体激活通路在抗磷脂综合征中的作用研究进展被引量：1

导出

摘要抗磷脂综合征（antiphospholipid syndrome，APS）是一种以反复发生动脉、静脉血栓、病态妊娠（妊娠早期流产和中晚期死胎）和血小板减少为特征的自身免疫病，血清中存在抗磷脂抗体（antiphospholipid antibody，aPL）。

作者王青松厉小梅

机构地区安徽医科大学附属省立医院风湿免疫科

出处《中华风湿病学杂志》 CAS CSCD 北大核心 2015年第7期487-489,共3页 Chinese Journal of Rheumatology

基金基金项目：国家自然科学基金（81373187）安徽省自然科学基金（1308085MH162）中华医学会l临床医学科研专项资金（12040730.373）

关键词抗磷脂综合征激活通路补体自身免疫病血小板减少抗磷脂抗体静脉血栓早期流产

参考文献20

1Meroni PL,Borghi MO,Raschi E,et al.Pathogenesis of antiphospholipid syndrome:understanding the antibodies[J].Nat Rev Rheumatol,2011,7(6):330-339.
2Ballanti E,Perricone C,Greco E,et al.Complement and au-toimmunity[J].Immunol Res,2013,56(2/3):477-491.
3Nayer A,Ortega LM.Catastrophic antiphospholipid syndrome:a clinical review[J].J Nephropathol,2014,3(1):9-17.
4Willis R,Harris EN,Pierangeli SS.Pathogenesis of the antiphospholipid syndrome[J].Clin Dev Immunol,2012,38(4):305-321.
5Bles J,Mackman N.Role of tissue factor in thrombosis in antiphospholipid antibody syndrome[J].Lupus,2010,19(4):370-378.
6Samarkos M,Mylona E,Kapsimali V.The role of complement in the antiphospholipid ayndrome:.a novel mechanism for pregnancy morbidity[J].Semin Arthritis Rheum,2012,42(1):66-69.
7Erkan D,Willis R,Murty VL,et al.A prospective open-label pilot study of fluvastatin on proinflammatory and prothrombotic biomarkers in antiphospholipid antibody positive patients[J].Ann Rheum Dis,2014,73(6):1176-1180.
8Nagata S.Apoptosis and autoimmune diseases[J].Ann NY Acad Sci,2010,1209:10-16.
9Gropp K,Weber N,Reuter M,.et al.b2-glycoprotein I,the major target in antiphospholipid syndrome,is a special human complement regulator[J].Blood,2011,118(10):2774-2783.
10Murthy V,Willis R,Romay-Penabad Z.Value of isolated IgA anti-p2GPI positivity in the diagnosis of the antiphospholipid syndrome[J].Arthritis Rheum,2013,65(12):1-33.

中华风湿病学杂志

2015年第7期

内容加载中请稍等...