布托啡诺治疗剖宫产术后寒战反应的疗效观察

Effect of butorphanol on shivering reaction after Caesarean section

目的观察布托啡诺对剖宫产术后寒战反应的治疗作用。方法 100例剖宫产术后发生寒战反应的产妇随机分为布托啡诺组(n=48)和非那根组(n=52)。布托啡诺组产妇给予布托啡诺1 mg肌肉注射,非那根组给予非那根25 mg肌肉注射。记录两组产妇用药前以及用药后5、10、20、30 min的寒战评分、Ramesay评分、血氧饱和度(Sp O2)、平均动脉压(MAP)、心率(HR)等指标。记录两组产妇恶心、呕吐、瘙痒等不良发应的发生情况。结果布托啡诺组产妇用药后各时段的寒战评分均低于非那根组(P<0.01)。两组产妇用药后的镇静评分较用药前增加(P<0.05或0.01),但两组间比较差异无统计学意义(P>0.05)。两组产妇各时段的MAP、HR、Sp O2以及不良反应的发生情况差异均无统计学意义(P>0.05)。结论布托啡诺治疗剖宫产术后寒战反应的效果优于非那根。

Objective To observe the effect of butorphanol on shiver reaction after Caesarean section. Methods One hundred cases of maternal shiver reaction occurred after Caesarean section were randomly divided into butorphanol group （n=48） and phenergan group （n=52）. Butorphanol group was treated with 1 mg butorphanol by intramuscular injection. Phenergan group received 25 mg promethazine by intramuscular injection, The indexes of shivering score, Ramesay score, blood oxygen saturation （SpO2）, mean arterial pressure （MAP） and heart rate （HR） were recorded before intramuscular injection and after 5, 10, 20, 30 min. The occurrence of nausea and vomiting, pruritus and other adverse the situation were recorded. Results After the treatment, the shivering score of butorphanol group was lower than that ofphenergan group （P〈0.01）. The Ramesay score of two groups after treatment increased comparing with that before treatment （P〈0.05 or 0.01）, but had no significant difference between the two groups （P〉0.05）. MAP, HR, SpO2 and the adverse reaction between the two groups were not statistically significant （P〉0.05）. Conclusion Effect of butorphanol on shivering reaction after uterine-incision delivery operation is better than promethazine.