焦虑水平及炎症因子对糖尿病患者白内障术后干眼的影响

Influence of anxiety levels and inflammatory factors on dry eye in diabetic patients after cataract surgery

目的探讨糖尿病患者白内障术后干眼症状、焦虑水平、炎症因子三者之间的关系。方法糖尿病患者晶状体超声乳化术后96例（96眼），通过汉密尔顿焦虑量表分为焦虑组及非焦虑组。于术后1周行泪膜破裂时间测定（BUT）、基础泪液分泌试验（SIt）、角膜荧光素染色（FL）、炎性因子检测及焦虑水平、干眼主观症状评分。结果糖尿病患者超声乳化术后1周，焦虑组与非焦虑组术后干眼主观症状、泪液指标（BUT、SIt、FL）及血清炎症因子中白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）及肿瘤坏死因子（TNF）含量的比较，差异均有统计学意义（P〈0．05）；患者干眼主观症状与焦虑水平、炎症因子指标均呈正相关（P〈0．05）。结论焦虑状态可激发炎症因子加剧糖尿病患者白内障术后的干眼症状。

Objective To investigate the correlation of dry eye symptom, anxiety level and inflammatory factor in diabetic patients after phaeoemulsification for cataract. Methods Ninty-six eyes of 96 diabetic patients after phacoemulsification were divided into anxiety groups and non-anxiety groups according to Hamilton Anxiety Scale. Tear film breakup time （BUT）, Schirmer test（ Sit）, Cornea fluorescein staining （FL）, inflammatory factor detection, anxiety level and dry eye subjective symptom scores were evaluated one week after operation. Results Dry eye subjective symptom, tear film indexes （ BUT, Sit and FL） and inflammatory factor （IL-113, IL-6, tumor necrosis factor ） in postoperative one week showed statistically significant differences between anxiety and non-anxiety group （ P 〈 0.05 ）. The dry eye subjective symptom was positively correlated to anxiety level as well as inflammatory factor （ P 〈 0. 05 ）. Conclusion Anxiety could aggravate dry eye subjective symptom in diabetic patients after phacoemulsification by stimulating the inflammatory factor.