控制性促排卵周期移植第6天血清孕酮/雌二醇水平与IVF/ICSI-ET临床结局的关系

Level of Serum P/E_2 on Day 6 after Embryo Transfer of COH and Clinical Outcomes of IVF/ICSI-ET

目的:探讨控制性促排卵(COH)周期中移植第6天血清孕酮/雌二醇(P/E2)水平对体外受精/卵胞浆内单精子显微注射-胚胎移植(IVF/ICSI-ET)临床结局的预测价值。方法:回顾性分析544个COH的IVF-ET周期,根据受试者工作特征曲线(ROC)将移植第6天P/E2比值分为2组:P/E2水平<114.5(A组)与P/E2水平≥114.5(B组),分析2组间一般临床特征、胚胎种植率和临床妊娠率的差异。结果:A、B组间的子宫内膜厚度、促性腺激素(Gn)用量、Gn时间及移植胚胎数等一般资料间差异无统计学意义(P>0.05),但A组胚胎种植率和临床妊娠率均高于B组,差异有统计学意义(P<0.05)。结论:COH周期移植第6天血清P/E2水平<114.5妊娠结局较好,对IVF-ET临床结局有一定预测价值。

Objective： To explore the relationship between the level of serum P/E2 on the day 6 after embryo transfer of cotrolled ovarian hyperstimulation and the clinical outcomes of IVF/ICSI-ET. Methods：A total of 544 cycles of IVF-ET were divided into two groups by the level of P/E2 on the day 6 after ET： group A（P/E2〈114.5） and group B（P/E2≥114.5）. The clinical data, implantation rate and clinical pregnancy rate were compared between two groups. Results：There were not significant differences between two groups in the endometrial thickness, total dose of gonadotropin, duration of gonadotropin and number of ET（P〉0.05）. However, the implantation rate and clinical pregnancy rate in the group A were significantly higher than those in the group B（P〈0.05）. Conclusions：The clinical outcomes will be better if the level of serum P/E2 on the day 6 after ET was lower than 114.5, suggesting that the level of serum P/E2 on the day 6 is a useful parameter predicting clinical outcomes of IVF.