基于BP神经网络的芪附汤对心肌缺血再灌注损伤大鼠ST值变化的影响研究

Study Effects of ST change about Qifu Decoction in Myocardial Ischemia-reperfusion Injury rats by BP neural network

目的运用BP神经网络模型,研究芪附汤对心肌缺血再灌注损伤大鼠ST值变化的影响。方法采用BP神经网络拟合心肌缺血再灌注损伤大鼠的ST值,得出大鼠ST值"时-效"曲线。根据"时-效"曲线,求算最大药效值(Emax)和药效峰值时间(Tmax),确立药效时间窗。结果通过对上述各药效参数的求算来综合评价芪附汤对心肌缺血再灌注损伤大鼠ST值变化的影响,客观的反映出芪附汤对心肌缺血再灌注损伤大鼠的时序性与整体性药效作用特点。结论该方法体现了芪附汤对心肌缺血再灌注损伤大鼠的时序性与整体性药效作用特征。

Objective By BP neural network model,to study the effects of ST change about Qifu Decoction in myocardial ischemia- reperfusion injury rats.Methods Use BP neural network to fit ST values in myocardial ischemia- reperfusion injury rats,to get ST value ＂time- effect＂curve in rats.According to ＂ time- effect＂ curve,calculate the maximum potency value（ Emax）and pharmacodynamic peak time（ Tmax）,establish the efficacy of the time window.Results Through the above calculation on pharmacodynamic parameters evaluated of Qifu Decoction to comprehensive evaluate the ST effects in myocardial ischemia reperfusion injury rats,objectively reflect the sequential and integrity pharmacodynamic effects of Qifu Decoction in myocardial ischemia- reperfusion injury rats.Conclusion The method reflects the Sequential and integrity Pharmacodynamic effects of Qifu Decoction in myocardial ischemia- reperfusion injury rats.