氧-18水批量回收纯化处理工艺

Batch Recycle Purification Technological Process of ^(18)O-H_2O Water

建立了一套18 O-H2O回收水批量回收纯化处理工艺。该工艺对18 O-H2O回收水中的杂质进行了分析,通过紫外杀菌,无菌滤膜过滤除去了菌类和细菌内毒素,通过三次低温蒸馏或C-18柱-二次低温蒸馏除去了可溶性无机和有机杂质,同时保证了同位素丰度符合要求,使18 O-H2O各项指标达到了加速器药物生产要求,并可达到较高的打靶和合成效率。该工艺的建立可以充分利用一次打靶后的18 OH2O回收水,大幅度降低了成本,资源利用更加合理,高效。

A batch purification technological process for ^18O-H2O recycled water is established. The impurities was analyzed firstly. The bacteria and endotoxin in ^18O-H2O recycled water could be removed by ultraviolet sterilize rand sterile membrane, and soluble impurities removed by multiple cryogenic distillation. This process makes indicators meet the accelerator pharmaceutical production requirements, together with high target and synthesis efficiency. This process, which takes advantages of ^18O-H2O recycled water produced by accelerator, reduces the cost significantly and utilizes the resources reasonably and efficiently.