摘要
目的探讨免疫组化法检测协同刺激分子B7-H4和干扰素调控因子2(IRF-2),对预测胰腺癌患者预后的价值,以指导临床治疗。方法应用免疫组化法检测B7-H4及IRF-2在67例原发性胰腺癌手术切除标本中的表达的,研究其表达情况与胰腺癌临床病理因素及患者预后的关系。结果 67例标本B7-H4阳性48例,平均染色积分(4.07±1.28)分;IRF-2阳性38例,平均染色积分(3.58±1.07)分,2者在胰腺癌中的表达呈正相关(P<0.05)。B7-H4的表达与卡氏功能状态(KPS)评分有关;IRF-2与TNM分期、肿瘤分化程度、肿瘤T分期有关。B7-H4或IRF-2阴性患者的预后显著优于其他患者(P<0.05),COX回归多因素分析显示,B7-H4高表达、IRF-2高表达、淋巴结转移及TNM分期为影响胰腺癌预后的独立因素。结论 B7-H4及IRF-2的高表达可能会促进胰腺癌的发展,联合检测两者有助于评价患者预后并指导疾病的长期治疗。
Objective To evaluate the prediction power of costimulatory molecules B7-H4 and interfer- on regulatory factor 2 （IRF-2） for the prognosis of patients with pancreatic cancer. Method B7-H4 and IRF-2 in cancer tissue samples were determined in 67 cases of primary pancreatic cancer surgery patients by im- munohistochemistry, and the relationship between B7-H4 and IRF-2, clinicopathological factors, and progno- sis was studied. Result B7-H4 positive was found in 48 cases, with the staining score being 4.07 _＋ 1.28, and IRF-2 positive in 38 cases, with the staining score being 3.58 _＋ 1.07. Chi square analysis indicated that there was a positive correlation between the expressions of B7-H4 and 1RF-2 in pancreatic cancer （P 〈 0.05）. Ex- pression of BT-H4 was related with Karnofsky performance status （KPS） score, while IRF-2 was related with TNM stage, tumor differentiation, and tumor T stage. B7-H4 or IRF-2 negative patients had better prognosis compared with B7-H4 or IRF-2 positive patients （P 〈 0.05）. COX regression analysis showed that high ex- pression of B7-H4 and IRF-2, lymph node metastasis, and TNM stage were independent factors influencing prognosis of pancreatic carcinoma. Conclusion High expression of B7-H4 and IRF-2 may promote the de- velopment of pancreatic cancer, combined detection of B7-H4 and IRF-2 may contribute for evaluating the prognosis of patients with pancreatic cancer.
出处
《现代消化及介入诊疗》
2015年第3期212-215,共4页
Modern Interventional Diagnosis and Treatment in Gastroenterology
