曼月乐联合益气化瘀汤对围绝经期功血患者的影响

Effect of Mirena Combined with Yiqihuayu Soup on Perimenopausal Dysfunctional Uterine Bleeding

目的观察曼月乐联合益气化瘀汤治疗围绝经期无排卵型功血的临床疗效及对患者血清NO的影响,探讨其作用机制。方法将60例PDUB患者随机分为治疗组和对照组各30例。对照组于诊刮后第二次月经期放置曼月乐,术后抗炎治疗,治疗组在对照组基础上予中药益气化瘀汤治疗。比较两组患者治疗前后阴道出血时间、子宫内膜厚度的变化和血清NO值的变化。结果治疗后两组阴道出血时间、子宫内膜厚度、血清NO值均较治疗前明显减少(P<0.05);治疗后治疗组阴道出血时间、子宫内膜厚度、血清NO值明显少于对照组(P<0.05)。结论曼月乐联合益气化瘀汤治疗围绝经期无排卵型功血临床疗效较好,主要通过改善子宫内膜脱落情况、调整血管舒缩功能及调节子宫动脉血流,达到止血的目的。

Objective To observe the efficacy of mirena combined with yiqihuayu soup in treating perimenopausal dysfunctional uterine bleeding（PDUB） and the effect on patients＇ serum NO, and to explore its action mechanism. Methods 60 PDUB patients were randomly divided into treatment group and control group, with 30 cases in each group. The control group was placed mirena in the second menstrual period after the diagnosis of scraping, and received anti-inflammatory therapy, the treatment group was given yiqihuayu soup on the basis of control group. The vaginal bleeding time, changes of endometrial thickness and serum NO level of two groups were compared.Results The vaginal bleeding time, endometrial thickness and serum NO level of two groups after treatment were decreased（P〈0.05）, and the vaginal bleeding time, endometrial thickness and serum NO level of treatment group were less than those of control group（P〈0.05）.Conclusions Mirena combined with yiqihuayu soup has better clinical effect in the treatment of PDUB, which achieves the goal of stopping bleeding mainly by improving endometrial loss situation, adjusting vasomotor function and regulating uterine artery blood flow.