摘要
目的探讨烟酸缺乏症的病因、发病机制、临床表现、实验室检查、脑电图特点、治疗及预后。方法本科收治合并亚急性脊髓联合变性的烟酸缺乏症1例,对其临床资料进行分析。结果烟酸缺乏症又称糙皮病,该病病因多种多样,夏秋季节多发,主要临床表现为"4D综合征",即皮炎,腹泻,痴呆及死亡。早期及时给予补充烟酸等综合处理后,预后较好,长期烟酸缺乏造成能量代谢障碍,引起维生素B12吸收及转运障碍,可继发周围及中枢神经损害。结论长期缺乏烟酸可以发生多系统的损害,早期治疗可改善预后。
Objective To explore the etiology, pathogenesis, clinical manifestation, laboratory examination, electroencephalogram （EEG） characters, therapy and prognosis of niacin deficiency. Methods To analyze the clinical datas by collecting one case diagnosed as niacin deficiency with subacute combined degeneration of spinal cord. Results Niacin deficiency, also called Pellagra, was characterized by ＂four D syndrome＂ as main clinical manifestations, namely dermatitis, diarrhea, dementia and death. Pellagra happened frequently between summer and autumn, the etionogy of the disease was multifarious. Treatment with niacin as early as possible may achieve good prognosis. Severe niacin deficiency could induce energy metabolic disturbance, combined with the secondary peripheral and central neurological damage, even subacute combined degeneration of spinal cord. Conclusion Multisystem lesions occur if niacin deficiency persists for a long term. Early diagnosis and treatment can improve the prognosis.
出处
《临床荟萃》
CAS
2015年第8期931-934,共4页
Clinical Focus
