C02激光切除联合干扰素γ疣体根部注射治疗甲周疣疗效观察

CO2 laser excision combined with injection of interferon-γ in wart root in treatment of periungual wart

目的探讨CO2激光切除联合干扰素γ疣体根部注射治疗甲周疣的临床效果。方法选取2013年2月至2014年2月我院皮肤科收治的80例甲周疣患者，将其随机分为观察组和对照组。对照组采用CO2激光切除治疗，观察组在对照组基础上加用干扰素γ疣体根部注射治疗，比较两组患者治疗效果、并发症及复发情况。结果观察组治疗总有效率为100．00％，明显高于对照组的90．00％，差异有统计学意义（P〈0．05）；观察组感染、低热、乏力、疼痛及肿胀不良反应发生率和对照组比较差异无统计学意义（P〉0．05）；观察组治疗1年后复发率为2．50％，明显低于对照组的20．00％，差异有统计学意义（P〈0．05）。结论CO2激光切除联合干扰素．γ疣体根部注射治疗甲周疣可提高治疗效果，降低复发率，具有较高治疗安全性，值得在临床中推广应用。

Objective To explore the clinical efficacy of CO2 laser excision combined with the injection of interferon-γ in wart root in the treatment of periungual wart. Methods 80 patients with periungual wart admitted into our department from February, 2013 to February, 2014 were selected and randomly divided into an observation group and a control group. The control group were treated with CO2 laser resection; and in addition, the observation group with the injection of IFN-γ in wart root. The efficacy, incidence of complications and recurrence were compared between these two groups. Results The total effective rate was 100.00% in the observation group and 90.00% in the control group, with a statistical difference （P〈0.05）. There were no statistical differences in the incidences of infection, fever, fatigue, pain, and swelling between these two groups （P〉0.05）. 1 year after the treatment, the recurrence rate was 2.50% in the observation group and 20.00% in the control group, with a statistical difference（P〈0.05）. Conclusions CO2 laser excision combined with the injection of interferon-γ in wart root in the treatment of periungual wart is effective and safe, can decrease recurrence rate, and is worth being clinically generalized.