期刊文献+

PTEN与肺癌的相关性研究进展 被引量:5

下载PDF
导出
摘要 肺癌是全球最常见的肿瘤,占所有肿瘤的13%,病死人数占肿瘤病死人数的18%[1]。在中国肺癌已成为城乡首位恶性肿瘤的死亡原因,占全部恶性肿瘤死亡的22.7%[2]。第10号染色体同源丢失性磷酸酶张力蛋白基因(phosphatase and tensin homolog deleted from chromosome 10,PTEN),是迄今为止发现的第一个具有磷酸酶活性的抑癌基因。
作者 张龙 蒋迎九
出处 《重庆医学》 CAS 北大核心 2015年第21期3002-3004,共3页 Chongqing medicine
基金 重庆市科技攻关计划项目(cctc2012gg-yyjs10055)
  • 相关文献

参考文献28

  • 1Jemal A, Bray F, Center MM, et al. Global cancer statis tics[J]. CA Cancer J Clin, 2011,61(2) : 69-90.
  • 2The Ministry of Health of the Peoplers Republic of Chi- na. Third National retrospect pot-check of death-causation [M]. Beijing:Peking Union Medical College Press, 2008 : 22.
  • 3Li J, Yen C, Liaw D, et al. PTEN,a putative protein tyro- sine phosphatase gene mutated in human brain, breast, and prostate cancer[J]. Science, 1997,275 (538) : 1943- 1947.
  • 4Vazquez F,Devreotes P. Regulation of PTEN function as a PIP3 gatekeeper through membrane interaction[J]. Cell Cycle,2006,5(14) : 1523-1527.
  • 5Hopkins BD, Hodakoski C,Barrows D, et al. PTEN func- tion:the long and the short of it[J]. Trends Biochem Sci, 2014,39 (4) : 183-190.
  • 6Hollander MC, Blumenthal GM, Dennis PA. PTEN loss in the continuum of common cancers, rare syndromes and mouse models[J]. Nat Rev Cancer, 2011,11 (4) : 289-301.
  • 7Tamguney T, Stokoe D. New insights into PTEN[J]. J Cell Sci, 2007,120(23) :4071-4079.
  • 8Li G, Zhao J, Peng X, et al. The mechanism involved in the loss of PTEN expression in NSCLC tumor cells[J]. Bio- chem Biophys Res Commun, 2012,418 (3) : 547-552.
  • 9Liu ZL,Wang H,Liu J,et al. MicroRNA-21 (miR-21) ex- pression promotes growth, metastasis, and chemo-or ra- dioresistance in non-small cell lung cancer cells by targe- ting PTEN[J]. Mol Cell Biochem, 2013,372(1/2) : 35-45.
  • 10Cai JC,Fatg LS, Huang YB,et al. miR-205 targets PTEN and PHLPP2 to augment ANT signaling and drive malig- nant phenotypes in Non-Small cell lung caneer[J]. Cancer Res,201373(17) :5402-5415.

同被引文献50

引证文献5

二级引证文献25

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部