Ghrelin在非酒精性脂肪性肝病发生发展中的作用

Role of Ghrelin in development and progression of nonalcoholic fatty liver disease

非酒精性脂肪性肝病(NAFLD)在我国的发病率逐年上升,成为仅次于病毒性肝炎的第二大肝病,其发生与胰岛素抵抗及氧化应激密切相关,是代谢综合征的重要组成之一。Ghrelin是新发现的生长激素促分泌素的内源性配体,其生物学作用广泛,不仅影响糖脂的代谢过程,对NAFLD的发生发展也有重要的作用。简述了内源性Ghrelin表达水平在NAFLD发生发展进程中的作用,指出通过调节Ghrelin水平来干预NAFLD的发生发展,将为NAFLD的临床治疗提供新的途径。

The incidence of nonalcoholic fatty liver disease（ NAFLD） has been increasing in China year by year,and NAFLD has become the second most common liver disease after viral hepatitis. Its development is closely associated with insulin resistance and oxidative stress and NAFLD is one of the important components of metabolic syndrome. Ghrelin is a newly discovered endogenous ligand for growth hormone secretagogue and has broad biological functions. Ghrelin not only affects the metabolic process of glucose and lipids,but also plays an important role in the development and progression of NAFLD. In this review,the role of endogenous Ghrelin expression in the development and progression of NAFLD is briefly summarized and the Ghrelin regulation in the development and progression of NAFLD is pointed out,which will provide new approaches to the clinical treatment of NAFLD.