非酒精性脂肪性肝病基因多态性的研究进展

Gene polymorphisms in non- alcoholic fatty liver disease: a review of research progress

非酒精性脂肪性肝病(NAFLD)被认为是全世界常见的慢性肝脏疾病之一,其发病率与种族、民族、家族、地区密切相关。近年来NAFLD与基因的关系越来越受到人们的重视,了解国际上影响NAFLD发病的相关基因多态性,对于遏制脂肪肝的发展趋势有着十分重要的意义。从葡萄糖代谢、脂肪酸代谢、氧化应激等相关基因的多态性对NAFLD发病的机制研究作一综述,指出NAFLD是一组遗传-环境-代谢应激相关的疾病。

Non- alcoholic fatty liver disease（ NAFLD） is considered one of the most common chronic liver diseases throughout the world.The incidence of NAFLD is closely associated with ethnicity,nationality,family,and region. In recent years,the association between NAFLD and gene has grown to be paid more attention. It is of great significance for inhibiting the prevalence of fatty liver disease to understand NAFLD and the gene polymorphisms associated with its pathogenesis. In this review,we summarize the gene polymorphisms associated with glucose metabolism,fatty acid metabolism,and oxidative stress in the pathogenic mechanisms of NAFLD and point out that NAFLD is a genetic- environment- metabolic stress disorder.