囊膜病毒膜融合分子机制研究进展

Recent Advances in Molecular Mechanism of Enveloped Viruses Membrane Fusion

囊膜病毒通过病毒与宿主细胞膜融合的方式感染宿主,病毒囊膜蛋白介导了膜融合过程。根据这些囊膜蛋白在病毒囊膜表面的排列、蛋白结构及其在融合肽中的位置不同,可将裳膜病毒分为三类,其利用这些囊膜特殊的蛋白分子与受体相互作用完成膜融合。在分子水平上研究这一过程有助于认识病毒侵染的本质和发现关键环节,达到预防与治疗病毒病的目的。

Enveloped virus infects the host by fusing with the membranes of the host cells. The membrane fusion progress is mediated by envelope glycoprotein of the virus. Enveloped viruses are grouped into three classes, according to the arrangement and structure and different positions in the fusion peptide of this envelope glycoprotein. These viruses fused with the membranes of the host cell through their particular glycoprotein interacting with receptor to finish the membrane fusion. Study on this process in molecular level conduces to find out the essence of virus infection as well as finding the crucial link, and achieve the goal of preventing and curing viral diseases.