中国缺血性脑卒中急性期抑郁障碍的性别差异

Poststroke Depression between Men and Women 2 Weeks after Ischemic Stroke in China

目的研究中国缺血性脑卒中急性期卒中后抑郁(PSD)的性别差异。方法选取"脑卒中后抑郁发生及其结局的前瞻性队列研究"库中1917例缺血性脑卒中患者,比较男女之间在卒中后2周PSD的发生率、抑郁表现及其影响因素。结果女性PSD的发生率明显高于男性(32.9%和26.6%,P<0.01),女性卒中评分与男性无显著性差异(P>0.05),17项汉密尔顿抑郁量表(HAMD-17)总分高于男性(P<0.05),抑郁表现均以迟滞和睡眠障碍为主。Logistic回归分析显示,女性PSD与既往心脏病史、精神障碍病史以及卒中严重程度相关,男性与年龄、吸烟史、精神障碍病史及卒中严重程度相关。结论缺血性脑卒中患者在急性期PSD发生率存在性别差异,PSD的影响因素也存在性别差异。

Objective To analyze the features of poststroke depression （PSD） between men and women after acute ischemic stroke in China. Methods A total of 1917 ischemic stroke patients were enrolled from the Prospective Cohort Study on Incidence and Outcome of Pa-tients with Poststroke Depression in China. The incidence of PSD and the features were compared between male and female patients. The factors related with PSD of every gender were extracted with Logistic regression analysis. Results The incidence of PSD was higher in wom-en than in men （32.9%vs. 26.6%, P〈0.01）. There was no difference in the stroke score between women and men （P〉0.05）. The score of Hamilton Depression Scale was higher in the women than in the men, and the features were similar. Logistic regression analysis indicated that the history of heart disease, history of mental disorders and stroke score related with PSD in women, while the age, history of mental dis-orders, smoking and stroke score in men. Conclusion The incidence and related factors of PSD 2 weeks after ischemic stroke are different between men and women.