妊娠晚期妇女B族溶血性链球菌带菌与妊娠结局的关系

The relation between maternal colonization of group B streptococcus in late pregnancy and the pregnancy outcome

目的：调查妊娠晚期妇女B族溶血性链球菌（group B streptococcus,GBS）带菌状况,探讨GBS带菌与不良妊娠结局的关系。方法：收集妊娠晚期孕妇462例,于孕35∽37周取阴道下1/3分泌物及肛周分泌物,应用荧光定量PCR法进行GBS检测,并观察其妊娠结局。结果：462例妊娠晚期孕妇GBS阳性者49例、带菌率约为10.61%;GBS阳性孕妇的宫内感染、产后出血和胎儿窘迫发生率高于GBS阴性组（P〈0.05）,而胎膜早破、早产发生率无显著性差异（P〉0.05）。结论：妊娠晚期GBS感染宫内感染、产后出血及胎儿窘迫的发生率升高,对妊娠结局有不良影响。

Objective： To investigate the status of maternal colonization of group B streptococcus（ GBS） in late pregnant women,and explore the relationship between the colonization of GBS and the adverse pregnancy outcome. Methods： The secretion from 1 /3 below vagina and around rectus was collected from 462 late pregnant women at gestation age 35-37 weeks. GBS was detected with fluorogenic quantitative PCR. Then the pregnancy outcome of the 462 women was surveyed. Results： 49 of the 462 women were GBS positive,and the GBS carrier rate of late-pregnant women was 10. 61%. The incidence of intrauterine infection,postpartum hemorrhage and fetal distress was higher in the GBS positive group than that of GBS negative group（ P〈0. 05）,while there was no significant difference in the incidence of premature rupture of memberane and premature birth between the two groups（ P〈0. 05）. Conclusions： GBS infection in late pregnant women can increase the incidence of intrauterine infection,postpartum hemorrhage and fetal distress,and has an adverse impact on the pregnancy outcome.