同型半胱氨酸与冠心病冠状动脉病变的相关性分析

CORRELATIONAL STUDY BETWEEN HOMOCYSTEININ AND CORONARY ATHEROSCLEROTIC DISEASE ON THE CORONARY ARTERY DISEASE

目的：探讨同型半胱氨酸（ Homocystein，Hcy）与冠心病患者冠状动脉病变程度的相关性。方法选取2013年1月∽2014年12月入住南方医科大学北滘医院的冠心病患者60例，所有入选患者均经冠状动脉造影并行 Genisi评分，检测外周血同型半胱酸表达；依据外周血同型半胱氨酸水平（ Hcy≥10μmol ／L定义为高 Hcy血症）分为冠心病组和冠心病并H同型半胱氨酸血症（ Hyperhomocysteinemia，HHcy）组。分析两组患者外周血Hcy水平、冠状动脉病变程度等表达水平和相互间相关性。结果与冠心病患者相比，冠心病并 HHcy 血症患者 Genisi 评分和外周血 Hcy 水平高于冠心病患者（ p＜0.05）；相关性分析显示所有入选患者外周血中Hcy水平与Genisi评分呈正相关（p＜0.05）。结论 HHcy血症是冠心病的重要危险因素，与冠心病冠状动脉病变程度正相关。

Objective To investigate correlational study on the levels of homocysteinin with the severity of coronary artery in patients with coronary atherosclerotic disease.Methods 60 patients with coronary atherosclerotic disease were enrolled in from Janu-ary 2013 to December 2014 in Beijiao hospital affiliated Southern medical university .All patients received coronary artery angiograph and the levels of circulating homocysteinin were determined.According to the levels of circulating homocysteinin, 60 patients were de-vided into coronary atherosclerotic disease group and coronary atherosclerotic disease group with hyperhomocysteinemia （ HHcy） .The levels of homocysteinin and the severity of coronary artery in patients with coronary atherosclerotic disease and correlation between the two group were analyzed.Results Compared with coronary atherosclerotic disease patients,the levels of homocysteinemia and Genisi score were increased in patients with coronary atherosclerotic disease with HHcy （p〈0.05）.Correlation analysis showed that the lev-els of homocystein is positively correlated with Genisi score （p〈0.05）.Conclusion HHcy is a important risk for coronary athero-sclerotic disease and positively related with the severity of coronary artery in patients with coronary atherosclerotic disease .