沙格列汀联合二甲双胍治疗老年2型糖尿病的效果观察

The effect of onglyza combined with metformin on the pancreatic β cell function of the senile patients with type 2 diabetes mellitus

目的观察沙格列汀联合二甲双胍治疗老年2型糖尿病的效果。方法将92例老年2型糖尿病患者随机分为观察组和对照组各46例。对照组给予二甲双胍及安慰剂治疗,观察组给予沙格列汀联合二甲双胍治疗。比较两组治疗前、治疗12周后空腹血糖(FPG)、餐后2 h血糖(2h PG)、糖化血红蛋白(Hb A1c)、体重指数(BMI)、血清C肽水平,以及治疗期间不良反应发生情况。结果观察组治疗后FPG、2h PG、Hb A1c、BMI及空腹、餐后2 h血清C肽水平改善明显优于对照组(P<0.01)。观察组治疗前后空腹及餐后2 h血清C肽水平差异显著(P<0.01)。两组治疗期间不良反应发生情况比较差异无统计学意义(P>0.05)。结论沙格列汀联合二甲双胍治疗老年2型糖尿病可有效降低患者空腹及餐后血糖,改善胰岛β细胞功能,不增加BMI,降低低血糖发生风险。

Objective To explore the effect of onglyza combined with metformin on the pancreatic β cell function of the senile patients with type 2 diabetes mellitus. Methods 92 senile patients with type 2 diabetes mellitus were randomly divided into the observation group and the control group,with 46 cases in each group. The patients in the control group were treated with metformin combined with placebo and the patients in the observation group were treated with metformin combined with onglyza. FPG,2h PG,Hb A1 c,BMI and serum C-peptide levels of the patients were compared between the two groups before and 12 weeks after the treatment. The adverse reactions during the therapy were compared between the two groups. Results The FPG,2h PG,Hb A1 c,BMI,fasting serum C-peptide and postprandial 2 h serum C-peptide level of the patients in the observation group were improved better than those of the patients in the control group（ P〈0. 01）. The fasting serum C-peptide and postprandial 2 h serum C-peptide level of the patients in the observation group were significant different before and after the treatment（ P〈0. 01）,and there was no significant difference in the adverse reactions between the two groups during the therapy（ P〈0. 05）. Conclusion Onglyza combined with metformin on the treatment for the senile patients with type 2 diabetes mellitus can lower the fasting and postprandial blood glucose and improve their pancreatic β cell function,control weight and lower hypoglycemia occurrence risk.