川龙抑癌汤联合TURP术治疗晚期激素非依赖性前列腺癌30例临床观察

Efficacy of Chuanlongyiai Decoction(川龙抑癌汤) combined with TUPR on Advanced Hormone-independent Prostate Cancer: A Clinical Observation of 30 Cases

目的:观察川龙抑癌汤联合TURP术治疗晚期激素非依赖性前列腺癌的临床疗效。方法:将符合纳入标准的经病理确诊为激素非依赖性前列腺癌患者共60例随机分为两组,每组各30例,对照组行TURP术;治疗组在此基础上予以川龙抑癌汤治疗。治疗后,观察两组患者临床症状的变化、PSA水平、最大尿流率、残余尿量、生活质量等指标的改变。结果:治疗后,治疗组临床总有效率为76.7%,明显高于对照组的56.7%;治疗组生存质量卡氏评分的有效率为90.0%,高于对照组的73.3%,两组比较,差异均有统计学意义(P<0.05);两组治疗后PAS水平、残余尿量等指标均较前显著降低(P<0.05),且治疗组较对照组下降更明显(P<0.05);两组治疗后最大尿流率均增加,与治疗前比较差异均具有统计学意义(P<0.05),且治疗组与对照组比较增加更明显(P<0.05)。结论:川龙抑癌汤联合TURP术治疗晚期激素非依赖前列腺癌的临床疗效佳,可明显改善患者的临床症状,提高生存质量,降低PAS水平。

[Abstract] Objective： To evaluate clinical efficacy of Chuanlongyiai Decoction combined with TUPR on advanced hormone- independent prostate cancer. Methods： The 60 cases which met the inclusion criteria were randomly divided into two groups, 30 cases in each. Patients were given TUPR treatment, and Chuanlongyiai Decoction （川龙抑癌汤） combined with TUPR in treat- ment group. Changes of clinical symptoms change, PSA level, maximum flow rate, residual urine volume, quality of life indica- tors were observed after treatment in two groups. Results： After treatment, the total effective rate of treatment group was 76.7%, which was significantly higher than the control group of 56.7%. The effective rate of Karnofsky score in the treatment group was 90.0%, which was higher than the control group of 73.3%. The differences were statistically significant （P〈0.05）; PAS level and residual urine volume were significantly lower after treatment （P〈0.05） in two groups, and the treatment group decreased more significantly than the control group （P〈0.05）. The maximum urinary flow rate increased in two groups, and the difference was sta- tistically significant （P〈0.05）. The treatment group increased more significantly than the control group（P〈0.05）. Conclusion： Chuanlongyiai Decoction combined with TUPR can provide good efficacy for advanced hormone-independent prostate cancer, improve the clinical symptoms, improve quality of life, and reduce PAS level.