歼击飞行员骨代谢生化指标调查

Survey of Bone Metabolism in Fighter Pilot

目的：探讨高空环境歼击飞行员的骨代谢生化指标变化及意义。方法：检测空军某部129名歼击飞行员（均为男性,身体健康,年龄26~48岁,平均飞行时间1500 h±100 h）的4项骨代谢生化指标：骨形成标志物N端骨钙素（N-MID）和总Ⅰ型胶原氨基端前肽（PINP）、骨吸收标志物β胶原降解产物（β-crosslaps）、调节钙平衡的甲状旁腺素（PTH）。根据机型分为二代机组与三代机组,结果采用t检验进行组间比较;按照年龄分为20~29岁、30~39岁、40~49岁年龄组,结果采用单因素方差分析进行组间比较。结果：2代歼击飞行员骨代谢生化指标比较差异无统计学意义。20~29岁年龄组中骨形成标志物N-MID和PINP浓度比其他年龄组明显升高,差异有统计学意义（P〈0.01）;20~29岁年龄组中骨吸收标志物β-crosslaps浓度比40~49岁年龄组显著升高,差异有统计学意义（P〈0.01）;骨吸收标志物PTH在各年龄组间的差异无统计学意义（P〉0.05）。结论：歼击飞行员骨形成标志物、骨吸收标志物在20~29岁达到最高水平,提示在人体峰值骨量时骨转换处于较高水平,40~60岁骨代谢生化指标浓度最低,骨吸收和骨形成处于动态平衡,骨转换水平较低。密切监测骨代谢生化指标变化,对维护飞行员骨健康,确保飞行安全有积极意义。

Objective：To investigate the changes of biochemical markers of bone metabolism and the possible sig-nificance in fighter pilots in high-altitude condition.Methods：To evaluate four biochemical markers of bone in129 fighter pilots（male,healthy,and aged 26~48 years,with an average flight time of 1500 h±100 h）：bone forma-tion marker N-terminal osteocalcin（N-MID）,total collagen typeⅠamino-terminal propeptide（PINP）,bone resorp-tion markers（β-crosslaps）,and parathyroid hormone（PTH）.The pilots were divided into two groups according toaircraft type,namely second-generation unit and three generations unit,and t test was used to compare the differ-ences between groups.The pilots were divided into three groups according to age,namely 20~29 year-old agegroup,30~39 year-old age group,and 40~49 age group,and ANOVA was used to compare the differences amongbiochemical markers.Results：The bone metabolic markers differences in two generations of fighter pilots were notstatistically significant.N-MID and PINP concentrations in 20~29 age group were significantly higher than thosein other age groups（P〈0.01）.In comparison to that in 40~49 age group,bone resorption markers β-crosslaps con-centration significantly increased in 20~29 age group（P〈0.01）.There were no significantly changes in PTH concen-tration（P〉0.05）.Conclusion：The markers of bone formation,and bone resorption reached the peak in the 20~29year-old pilots,suggesting that a high level of bone turnover happens in the period of peak bone mass.The bonemetabolic markers were at the lowest concentration in 40~60 years-old pilots,indicating that bone resorption andbone formation are in a dynamic equilibrium,and the level of bone turnover is low.Close monitoring the changesin bone metabolism has a positive significance for maintaining bone health and ensuring flight safety of pilots.