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干细胞治疗脑梗死的应用和安全性的研究进展 被引量:4

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摘要 近年来,干细胞移植治疗脑梗死得到了越来越多学者的关注和研究。移植的细胞可分泌大量神经生长因子改善微环境,促进神经再生、抑制炎症反应,还可分化增殖,替代受损神经元,重建神经通路。大量实验已证明干细胞治疗脑梗死的可行性和有效性,但目前细胞治疗应用仍处于初级阶段,许多问题仍未解决,如移植时间、移植方式、移植的安全性等。本文综述相关文献,探讨上述问题。
作者 王觅 段淑荣
出处 《神经损伤与功能重建》 2015年第4期329-331,共3页 Neural Injury and Functional Reconstruction
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  • 1Otrock ZK, Makarem JA, Shamseddine ALVascular endothelial growth factor family of ligandsand receptors: Review[J]. Blood Cells Mol Dis, 2007,38:258-268.
  • 2Oshikawa J, Urao N, Kim HW,et al. ExtracellularSOD-derived H202 promotes VEGF signaling incaveolae^ipid rafts and post-ischemic angiogenesis inmice[J]. PLoS One, 2010,5:el0189.
  • 3Jin F,Hagemann N, Brockmeier U, et al. LDLattenuates VEGF-induced angiogenesis viamechanisms involving VEGFR2 internalization anddegradation following endosome-trans-Golgi networktrafficking [J]. Angiogenesis, 2013,[Epub ahead ofprint].
  • 4Robinson CJ, Stringer SE. The splice variants ofvascular endothelial growth factor (VEGF) and theirreceptors[J]. J Cell Sci, 2001,114:853-865.
  • 5Jin K, Mao X, Xie et al. Interactions betweenvascular endothelial growth factor and neuroglobin[J].Neurosci Lett, 2012,519:47-50.
  • 6Sun Q, Chen RR, Shen Y, et al. Sustained vascularendothelial growth factor delivery enhancesangiogenesis and perfusion in ischemic hind limb [J].Pharm Res, 2005,22:1110-1116.
  • 7Lopez-Aguilera F, Plateo-Pignatari MG’ Biaggio V,et al Hypoxic preconditioning induces an AT2-R/VEGFR-2 (Flk-1) interaction in the neonatal brainmicrovasculature for neuroprotection [J].Neuroscience, 2012,216:1-9.
  • 8Urbinati C, Ravelli C, Tanghetti E, et al.Substrate-immobilized HIV-1 Tat drives VEGFR2/a(v)p(3)-integrin complex formation and polarization inendothelial cells [J]. Arterioscler Thromb Vase Biol,2012,32:e25-34.
  • 9Nakamura Y,Patrushev N, Inomata H, et aL Role ofprotein tyrosine phosphatase IB in vascularendothelial growth factor signaling and cell-celladhesions in endothelial cells [J]. Circ Res, 2008,102:1182-1191.
  • 10Kinugasa M, Amano H, Satomi-Kobayashi S, etal. N ecl-5^)oliovirus receptor interacts with VEGFR2and regulates VEGF-induced angiogenesis [J]. CircRes, 2012,110:716-726.

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