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戊型肝炎病毒开放阅读框3分子生物学特性及其功能研究进展 被引量：1

Molecular biological characteristics and functions of hepatitis E virus open reading frame 3:review of recent progress
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摘要 戊型肝炎（hepatitis E,HE）是由戊型肝炎病毒（hepatitis E Virus,HEV）引起的病毒性肝炎,多发生在卫生条件较差的地域,主要经粪-口途径传播,以水源性、食源性传播较为多见。目前根据核苷酸同源性分析,HEV至少存在4个基因型,分别为基因1～4型。研究显示,基因1型和2型HEV只感染人,与发展中国家戊型肝炎大的暴发或流行有关,主要由于水源污染导致;基因3型和4型HEV既可感染人，也可感染多种动物，为人畜共患病原体，常引起散发病例，主要传染源为动物，特别是猪，其中3型呈全球性分布，4型主要流行于亚洲。 Hepatitis E virus （HEV） was first documented as an infectious agent in 1980s. The HEV genome contains three open reading frames （ORFs）. The genome structure and function of ORF1 and ORF2 have been thoroughly studied; however, knowledge for the molecular characteristics and biological functions of HEV ORF3 is still limited. It has recently been proven that HEV ORF3 protein interacts with many intracellular sig- nal proteins which may play a role in cell signaling transduction, virus replication and release during HEV in- fection.
作者 曾航 王玲
机构地区 北京大学医学部基础医学院病原生物学系和感染病中心
出处 《中国病毒病杂志》 CAS 2015年第3期223-227,共5页 Chinese Journal of Viral Diseases
基金 国家自然科学基金(81271827) 高等学校博士学科点专项科研基金(20120001110098)
关键词 戊型肝炎病毒 分子生物学特性 开放阅读框 Hepatitis E Virus Molecular characteristics Open reading frame
分类号 R373 [医药卫生—病原生物学]
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参考文献39

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二级参考文献15

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共引文献1

同被引文献24

  • 1朱光泽,屈勇刚,孙中峰,李红文,郭玉花.HEV国内外研究现状及目前所面临的问提[J].中国实验诊断学,2006,10(8):937-939. 被引量：11
  • 2姚敏芳,黄莉芳.张家港市一般人群戊型肝炎感染情况调查[J].江苏预防医学,2007,18(2):21-23. 被引量：4
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中国病毒病杂志
2015年 第3期

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