NF-κB在膝关节骨性关节炎治疗中的应用研究进展

Research Progress in Application of NF-κB Treating Knee Osteoarthritis

膝关节骨性关节炎会造成患者不能负重、行走困难,对患者的生活造成极大影响,且常规治疗效果不甚理想.而NF-κB通过因子与DNA的结合,启动相关基因转录,可对膝关节骨性关节炎起到较好效果.通过对NF-κB在膝关节骨性关节炎中的治疗研究,可以总结近阶段的临床研究成果,对病症的治疗及发展具有较大的参考价值.

Knee osteoarthritis makes patients unable to bear load and difficult to walk, which greatly affects patient＇s living, and effect of convention-al treatment is not so ideal. NF-κB binding factor and DNA, initiating related gene transcription, can play a better role in knee osteoarthritis. Based on research of NF-κB treating knee osteoarthritis, clinical research achievement in recent stage can be summarized, which has great reference value to the treatment and development of the disease.