摘要
鹅绒藤属植物在我国分布广泛,且大部分具有药用价值.甾体皂苷,该属植物的主要成分,表现出极大的结构多样性.化学结构多样性体现在母核(甾体苷元)、母核取代基、糖链长度、单糖种类、绝对构型(D或L)以及糖链中糖苷键的类型(α或β),特别是在同一个糖链中同时存在D-糖和L-糖的情况在其它天然产物中并不多见,糖链长度多达7个单糖的结构在糖苷类化合物中也十分罕见.从母核和其取代基的角度将2007-2014年从该属植物中分离出来的新甾体皂苷共119个,归纳为5种17亚种.同时也对该属植物甾体皂苷的生物活性如抗肿瘤、抗病毒、神经保护和杀虫等进行了综述.
Cynanchum species are widely distributed in China, and most of them have medicinal value. Steroidal saponins, the main component of this genus, demonstrate a rich diversity. The chemical diversity includes variable nucleus （steroid aglycone） , Substituents, length of sugar chain, monosaccharide type, absolute configuration （D or L）of a monosaccharide, type （oL or ~）of a glycoside bond. Especially,it is rare occurrence of a natural compound that possesses a sugar with both D- and L- monosaccha- ride, and it is also uncommon for glycosides bearing a sugar chain which is assembled by seven units of monosaccharide. Based on the nucleus and its substituent, a total of 119 steroidal saponins isolated from this genus between 2007 and 2014, were grouped into five kinds of 17 subspecies. In addition, bioactivity of the saponins including antitumor, antiviral, neuroprotective and insecticidal effects are reviewed.
出处
《西南民族大学学报（自然科学版）》
CAS
2015年第4期423-431,共9页
Journal of Southwest Minzu University(Natural Science Edition)
基金
西南民族大学2015年省级大学生创新创业训练计划项目(NO.S201510656126)
关键词
鹅绒藤属
甾体皂苷
糖链
抗肿瘤
抗病毒
神经保护
杀虫
Cynanchum
steroidal saponin
sugar chain
antitumor
antiviral
neuroprotective
insecticidal
