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Glucagon peptide-like 1 receptor (GLP-1R) expression per se: a new insight into neurodegenerative disease?

Glucagon peptide-like 1 receptor (GLP-1R) expression per se: a new insight into neurodegenerative disease?
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摘要 Glucagon peptide-like 1（GLP-1）and GLP-1 receptor（GLP-1R）：GLP-1 is an incretin hormone secreted from gut L cells.GLP-1 exerts its action through binding to its specific receptor,GLP-1R,which is a member of the G protein-coupled receptor superfamily.GLP-1R is reportedly expressed in various organs,such as the liver,kidney,and peripheral tissues. Glucagon peptide-like 1（GLP-1）and GLP-1 receptor（GLP-1R）：GLP-1 is an incretin hormone secreted from gut L cells.GLP-1 exerts its action through binding to its specific receptor,GLP-1R,which is a member of the G protein-coupled receptor superfamily.GLP-1R is reportedly expressed in various organs,such as the liver,kidney,and peripheral tissues.
作者 Dong-il Kim Soo-hyun Park
机构地区 College of Veterinary Medicine
出处 《Neural Regeneration Research》 SCIE CAS CSCD 2015年第7期1055-1057,共3页 中国神经再生研究（英文版）
基金 supported financially by a research grant from National Research Foundation of Korea(NRF-2010-0023627)
关键词 GLP-1R a new insight into neurodegenerative disease expression per se Glucagon peptide-like 1 receptor
分类号 R741 [医药卫生—神经病学与精神病学]
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  • 1Aviles-Olmos I, Dickson J, Kefalopoulou Z, Djamshidian A, Ell P, Soderlund T, Whitton P, Wyse R, Isaacs T, Lees A, Limousin P, Fol- tynie T (2013) Exenatide and the treatment of patients with Parkin- son's disease. J Clin Invest 123:2730-2736.
  • 2Bomfim TR, Forny-Germano L, Sathler LB, Brito-Moreira J, Houzel JC, Decker H, Silverman MA, Kazi H, Melo HM, McClean PL, Holscher C, Arnold SE, Talbot K, Klein WL, Munoz DP, Ferreira ST, De Felice FG (2012) An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Abeta oligomers. J Clin Invest 122:1339-1353.
  • 3During MJ, Cao L, Zuzga DS, Francis JS, Fitzsimons HL, Jiao X, Bland RJ, Klugmann M, Banks WA, Drucker DJ, Haile CN (2003) Gluca- gon-like peptide-1 receptor is involved in learning and neuroprotec- tion. Nat Meal 9:1173-1179.
  • 4Fan Y, Liu K, Wang Q, Ruan Y, Ye W, Zhang Y (2014a) Exendin-4 alle- viates retinal vascular leakage by protecting the blood-retinal barrier and reducing retinal vascular permeability in diabetic Goto-Kakizaki rats. Exp Eye Res 127:104-116.
  • 5Fan Y, Liu K, Wang Q, Ruan Y, Zhang Y, Ye W (2014b) Exendin-4 protects retinal cells from early diabetes in Goto-Kakizaki rats by increasing the Bcl-2/Bax and Bcl-xL/Bax ratios and reducing reactive gliosis. Mol Vis 20:1557-1568.
  • 6Kim DI, Park MJ, Choi JH, Lim SK, Choi HJ, Park SH (2015) Hypergly- cemia-induced GLP-1R downregulation causes RPE cell apoptosis. Int J Biochem Cell Bio159:41-51.
  • 7Li Y, Perry T, Kindy MS, Harvey BK, Tweedie D, Holloway HW, Powers K, Shen H, Egan JM, Sambamurti K, Brossi A, Lahiri DK, Mattson MP, Hoffer BJ, Wang Y, Greig NH (2009) GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism. Proc Natl Acad Sci U S A 106:1285-1290.
  • 8Mima A, Hiraoka-Yamomoto J, Li Q, Kitada M, Li C, Geraldes P, Mat- sumoto M, Mizutani K, Park K, Cahill C, Nishikawa S, Rask-Madsen C, King GL (2012) Protective effects of GLP-1 on glomerular endo- thelium and its inhibition by PKCbeta activation in diabetes. Diabe- tes 61:2967-2979.
  • 9Ninomiya T (2014) Diabetes mellitus and dementia. Curr Diab Rep 14:487.
  • 10Pan QR, Li WH, Wang H, Sun Q, Xiao XH, Brock B, Schmitz O (2009) Glucose, metformin, and AICAR regulate the expression of G pro- tein-coupled receptor members in INS-1 beta cell. Horm Metab Res 41:799-804.
Neural Regeneration Research
2015年 第7期

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