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Rho激酶抑制剂:治疗神经系统变性疾病的潜在药物 被引量:4

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摘要 近10年来,由于神经影像和分子生物学迅速发展,神经系统变性疾病的诊断取得了长足进步。相比之下,其治疗仍然举步维艰。了解神经变性的细胞和分子机制,寻找真实有效的干预靶点、提高疾病预防和治疗效果是临床神经科学迫切需要解决的现实问题。近年来人们发现诸多神经变性病呈现相似的病理和重叠的临床表现,它们之间存在类似的细胞和分子机制,免疫炎性反应形成的微环境是其共同的细胞学通路,而其中Rho激酶(ROCK)的异常激活可能是其共同的分子机制之一。研究表明通过抑制ROCK的活性能够减少免疫细胞的炎性反应、抑制中枢神经系统一氧化氮(NO)、白细胞介素1β(IL-1β)、白细胞介素6(IL-6)和肿瘤坏死因子α(TNF-α)等炎性因子产生,改善炎性微环境保护神经元,同时抑制ROCK活性还可促进神经突触再生和神经干细胞动员分化。综上,ROCK抑制剂(Rho kinase inhibitor,RKI)有可能成为神经变性疾病的潜在药物。本文就RKI治疗神经系统变性疾病的潜在可能和相应机制进行简要综述。
出处 《中国神经免疫学和神经病学杂志》 CAS 2015年第4期288-290,295,共4页 Chinese Journal of Neuroimmunology and Neurology
基金 国家自然科学基金2012年面上项目(81272163) 山西省国际科技合作项目(2013081058) 山西省回国留学人员重点科研资助项目(2014-重点7) 山西中医学院“2011”培育计划项目(2011PY-1) 山西省自然科学基金项目(2008011082-1)
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共引文献17

同被引文献56

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