摘要
目的分析应用小剂量丙泊酚（PPF）联合氯胺酮（KTM）镇静麻醉对于骨科患儿认知功能的影响情况并评价镇静治疗用药的安全性。方法将7～12岁的骨科患儿64例随机分成观察组（36例，0．25mg／kg的PPF＋0．25mg／kg的KTM）和参照组（28例，0．5mg／kg的PPF＋0．5mg／kg的KTM），在换药镇静前后各12h采用自制认知功能量表对两组患儿进行评价，并记录、比较镇静后12h内两组患儿的意识恢复时间、不良反应发生情况。结果认知功能评分方面，两组患儿在换药镇静前无显著差异（P〉0．05），而在换药镇静后观察组明显高于对照组（P〈0．05）；在安全性上，与对照组相比，观察组患儿的意识恢复时问更短、不良反应发生率更低，且存在显著差异（P〈0．05）。结论采用小剂量的PPF联合KTM在换药时对骨科患儿进行镇静治疗，可有效减少PPF对患儿神经系统、认知能力的影响及相关不良反应，并促使患儿在镇静治疗后快速恢复意识，值得在骨科临床中应用、实践。
Objective To analyze the effect of low - dose propofol （PPF） combined with ketamine （KTM） sedation anesthesia for the patients with department of orthopedics and to evaluate the safety of sedation for the treatment of drug. Methods The 7 - 12 in pediatric orthopedics 64 cases were randomly divided into observation group （36 cases, 0.25 mg/kg PPF ＋ 0.25 mg/kg KTM） and reference group （28 cases, 0. 5 mg/kg PPF ＋0.5 mg/kg KTM）, in 12 h before and after dressing sedation by using self - made cognitive function scale of two groups of patients were evaluated, and note book, after relatively calm within 12 h of two groups of children of consciousness recovery time and adverse reactions occurred. The cognitive function score, two groups of children in dressing before sedation without significant difference （ P 〉 0. 05）, and after dressing change of sedation in the observation group was significantly higher than that of control group （ P 〈 0. 05 ） ; in safety. Compared with the control group, observation group with the consciousness recovery time shorter, adverse reactions occur rate is lower, and there significant difference （P 〈 0. 05 ）. Conclusion The use of small dose of PPF with KTM in dressing change of pediatric orthopedics sedation, can effectively reduce the PPF to the nervous system in children, cognitive ability, and adverse reaction, and make children in sedation after the rapid return of consciousness, it is worth in clinical orthopaedics, practice.
出处
《广东微量元素科学》
CAS
2015年第6期31-34,共4页
Trace Elements Science
