亚临床甲状腺功能减退与妊娠期糖尿病的相关性分析

Correlation analysis of the clinical characteristics in pregnancy women complicated with subclinical hypothyroidism and gestational diabetes mellitus

目的：：探讨亚临床甲状腺功能减退（ SCH）对GDM病情的影响程度。方法：选取2013年4月~2014年8月于我院就诊的GDM合并SCH孕妇共244例（研究组）,根据孕妇及非孕人群血清TSH的正常值上限,将其中110例TSH〉4.0 mU/L者归为研究组A,134例TSH 2.5~4.0mU/L者归为研究组B。另取同期就诊的甲状腺功能正常的GDM孕妇120例作为对照组。分析3组患者的临床资料。结果：3组孕妇的空腹血糖、糖化血红蛋白、糖化血清蛋白等比较,差异均无统计学意义（P〉0.05）。但研究组孕妇的胰岛素使用率均高于对照组,胰岛素敏感指数（ ISI）和胰岛分泌功能指数（ IFI）则低于对照组（ P〈0.05）。结论：合并SCH的GDM孕产妇,其胰岛功能受损情况更为严重,使用胰岛素的概率升高。

Objective：To evaluate the influence of subclinical hypothyroidism on gesta-tional diabetes mellitus. Methods：The data of 244 cases of pregnant patients complicated with gestational diabetes mellitus and subclinical hypothyroidism were analyzed retrospectively. Ac-cording to the value of TSH,these patients were divided into two groups：110 cases in group A whose TSH〉4. 0 mU/L,and 134 cases in group B whose TSH between 2. 5mU/L and 4. 0mU/L. Otherwise there were 120 gestational diabetes mellitus patients with normal thyroid function in the control group. Results：There were no difference among the three groups in fast plasma sugar,glycosylated hemoglobin,glycosylated serum protein（P〉0. 05）. The ISI and IFI in group A and group B were significantly lower than those in the control group. The rate of insulin injec-tion were higher in group A and group B（P〈0. 05）. Conclusions：The islet functions of patients complicated with gestational diabetes mellitus and subclinical hypothyroidism are more seriously injured. And more of these patients need to use insulin.