维吾尔族早发冠状动脉粥样硬化性心脏病患者中医证型分布及危险因素分析

Analysis of TCM Syndrome Distribution and Risk Factors of Premature Coronary Atherosclerotic Heart Disease of Uygur People

目的:探讨维吾尔族早发冠状动脉粥样硬化性心脏病(冠心病)患者中医证型分布及危险因素。方法:选择维吾尔族与汉族冠心病患者各220例,分别列为观察组1和观察组2,观察其中医证型分布,匹配选择维吾尔族与汉族正常人各220例,分别列为对照组1和对照组2,对比分析维吾尔族冠心病危险因素。结果:1观察组1冠心病中医证型以秽浊痰阻证、气虚血瘀证为主,构成比分别为44.27%、19.09%,观察组2分别为37.73%、22.27%,两组比较秽浊痰阻构成比有统计学意义(χ2=16.712,P<0.05);2观察组1与观察组2冠心病男性构成比分别为65.00%、66.82%,高于女性的35%、33.18%,其中观察组1男性冠心病患者平均年龄低于观察组2,差异有统计学意义(P<0.05);3观察组1与对照组1两组在吸烟、饮酒、高血压、糖尿病、BMI>24.0 kg·m2、冠心病家族史率,TC、TG、LDL-c、LP(a)、Fib水平差异有统计学意义(P<0.05),观察组2与对照组2两组在吸烟、糖尿病、BMI>24.0 kg·m2、冠心病家族史率,TC、TG、LDL-c水平差异有统计学意义(P<0.05);4性别、年龄、吸烟、饮酒、高血压、糖尿病、肥胖、冠心病家族史、高TC、LP(a)是维吾尔族冠心病独立危险因素(P<0.05)。结论:维吾尔族冠心病患者中医证型以秽浊痰阻证为主,性别、年龄、吸烟、饮酒、高血压、糖尿病、肥胖、冠心病家族史、高TC及LP(a)是其危险因素。

Objective： To discuss the TCM syndrome distribution and risk factors of premature coronary atherosclerotic heart disease（ coronary heart disease,CHD） of Uygur people. Methods： 220 Uygur people with CHO and 220 Han people with CHO were selected and divided into respective observation group1 and observation group 2. The TCM syndrome distribution was observed,and matched with 220 healthy Uygur people and 220 healthy Han people respectively and divided into control group 1 and control group 2. The risk factors of Uygur CHO were compared and analyzed. Results： 1） In observation group 1,the TCM syndromes are mainly turbid-phlegm obstruction syndrome,qi deficiency and blood stasis syndrome with the component percentages of 44. 27%,19. 09% respectively while 37. 73%,22. 27% in observation group 2. By comparison,the component percentage of turbid-phlegm obstruction syndrome has statistical significance（ χ^2= 16. 712,P〈0. 05）; 2） the component percentages of male patients with CHD in observation group 1 and observation group 2 were respectively 65% and 66. 82%,higher than the 35% and 33. 18% of female patients with CHD. The average age of male patients with CHD in observation group 1 was younger than those in observation group 2; the difference had statistical significance（ P〈0. 05）. 3） The differences in smoking,drinking,hypertension,diabetes,BMI 24. 0 kg·m^- 2,history rate of CHD,levels of TC,TG,LDL-c,LP（ a） and Fib between observation group 1 and control group 1 had statistical significance（ P〈0. 05）. The same was true for observation group 2 and control group 2. 4） Gender,age,smoking,drinking,hypertension,diabetes,obesity,family history of CHD,high levels of TC and LP（ a） are the independent risk factors of Uygur CHD（ P〈0. 05）. Conclusion： The TCM syndrome of CHD among Uygur people is mainly the turbid-phlegm obstruction syndrome,and gender,age,smoking,drinking,hypertension,diabetes,obesity,family history of CHD,high levels of TC and LP（ a） are the risk factors of it.