原发性三叉神经痛的多模态MRI研究进展

Study progress of multimodal magnetic resonance imaging in classical trigeminal neuralgia

原发性三叉神经痛(TN)是最常见的颅神经疾病之一,以三叉神经感觉支分布区反复发作的触电样剧烈疼痛为临床特征,病因不明。多模态MRI技术能够全面评估三叉神经脑池段与邻近血管的毗邻关系、三叉神经形态学改变、三叉神经纤维束的完整性以及相关脑区的结构与功能改变,可以为深入理解TN的发病机制、指导治疗方案的制定以及预后评估提供大量有价值信息。现就多模态MRI技术在TN研究中的技术进展和发展现状予以综述。

Classical trigeminal neuralgia（TN） is one of the most common diseases of cranial nerves and characterized by recurrent episodes of severe electric shock-like pain in the sensory supply areas of trigeminal nerve, without an established etiology. Multimodal magnetic resonance imaging（MRI） techniques can fully evaluate the neurovascular contact at cisternal segment of trigeminal nerve, morphological changes of trigeminal nerve, fiber integrity of trigeminal nerve,structural and functional alternations in related brain areas, which can help to understand the pathogenesis of TN, guide development of treatment strategy and predict outcome of microvascular decompression. In this article, the technological progress and current development of multimodal MRI in classical TN were reviewed.