益肾壮骨汤治疗骨质疏松症临床研究

Clinical Study on Kidney-Benefiting and Bone-Strengthening Decoction for Treating Osteoporosis

目的:观察益肾壮骨汤联合仙灵骨葆胶囊治疗骨质疏松症的临床疗效。方法:将2012年3月—2014年10月本院诊治的骨质疏松症患者116例,随机分为对照组和观察组各58例。对照组患者给予仙灵骨葆胶囊治疗,观察组患者在对照组基础上给予益肾壮骨汤内服治疗,1剂·d-1,连续治疗6个月。观察两组患者临床疗效。结果:对照组有效率为75.9%,明显低于观察组有效率91.3%,差异有统计学意义(P<0.05);患者经治疗后疼痛症状明显缓解,VAS评分随着治疗时间的延长而降低,以观察组的降低幅度更为明显,差异有统计学意义(P<0.05);患者经治疗后L2-L4椎骨及股骨颈的骨密度均较治疗前升高,观察组的变化幅度明显高于对照组,差异有统计学意义(P<0.05);两组患者经治疗后骨代谢生化指标水平改善明显,β-I型胶原羧基端肽(β-CTX)、碱性磷酸酶水平均较治疗前降低,而血清钙、骨钙素水平则较治疗前升高,以观察组的改善程度更突出,差异有统计学意义(P<0.05)。结论:益肾壮骨汤联合仙灵骨葆胶囊能有效缓解骨质疏松症患者的疼痛症状,提高骨密度,促进骨形成,疗效显著。

Objective： To observe the clinical effect of Kidney-Benefiting and Bone-Strengthening Decoction combined with Xianling Gubao Capsules on osteoporosis. Methods： 116 cases with osteoporosis received by this hospital from March,2012 to October,2014 were randomized into control group and observation group,with 58 cases in each group. Control group were given Xianling Gubao Capsules and observation group were additionally given Kidney-Benefiting and Bone-Strengthening Decoction for oral administration,with one dosage every day. After 6 months of treatment,the clinical effect of both groups were observed. Results： The effective rate in control group（ 75. 9%） was obviously lower than that in observation group（ 91. 3%）; the difference had statistical significance（ P 〈0. 05）. The pain of the patients got obviously improved after the treatment. The VAS declined with the process of the treatment and the decline in observation group was much more obvious,with statistical significance（ P 〈0. 05）. The bone mineral density of L2-L4 vertebra and collum femoris increased after the treatment and the change in observation group was bigger than that in control group,with statistical significance（ P 〈0. 05）. The levels of biochemical indexes of bone metabolism of both groups improve markedly; the levels of β-CTX and alkaline phosphatase declined while the levels of serum calcium and osteocalcin increased after the treatment; the improvement of observation group was much much remarkable and the difference had statistical significance（ P 〈0. 05）. Conclusion： Kidney-Benefiting and Bone-Strengthening Decoction combined with Xianling Gubao Capsules can relieve the pain of patients with osteoporosis,increase the bone mineral density and promote bone formation with remarkable efficacy.