ELAM-1在鼻咽癌组织中表达及其与临床特征关系的研究

EXPRESSION OF ELAM-1 IN NASOPHRYNGEAL CARCINOMA AND ITS CORRELATION WITH CLINICAL FEATURE

目的:探讨内皮性白细胞黏附分子-1(ELAM-1)在鼻咽癌组织中的表达及其与临床特征的关系。方法:应用免疫组织化学染色技术检测46例鼻咽癌患者组织中ELAM-1的表达,按转移与否分为转移组和非转移组,比较两组ELAM-1表达的阳性率,并分析ELAM-1表达等级与T分期、临床TNM分期、年龄和性别之间的关系。结果:46例鼻咽癌患者中,29例发生转移,转移率为63%。转移组ELAM-1表达的阳性率为93.1%(27/29),非转移组ELAM-1表达的阳性率为23.5%(4/17),两组阳性率比较差异有统计学意义(χ2=23.607,P=0.000),并且转移与ELAM-1表达等级呈正相关关系(rs=0.571,P=0.000)。ELAM-1表达等级与T分期、临床TNM分期、年龄、性别无关(P>0.05)。结论:ELAM-1异常表达有助于鼻咽癌预后判断,但与临床特征中的预后因素无相关性。

Objective： To investigate the expression of EMLA-1 in nasopharyngeal carcinoma （NPC） and its correlation with clinical feature. Methods： Immunohistochemical SP method was used to detect the expression of EMLA-1 in 46 NPC tissues. And these samples were divided into metastasis group and non-metastasis group according metastatic condition. Then, compared the positive rate of ELAM-1 in the two groups and analyzed the relationship between the expression grade of ELAM-1 and clinical parameters including age, gender, clinical stage, T stage. Results： 29 cases of 46 case with NPC had occurred metastasis and the rate of metastasis accounted for 63%. Among the metastasis group, 93.1% （27/29） tissues expressed E- LAM-1, while the positive rate of ELAM-1 in non-metastasis was just 23.5% ,there was significant different between the positive rate of ELAM-1 in the two groups （χ^2=23. 607, P =0. 000）. Furthermore, statistic analyze showed that there was a positive correlation between the grade of ELAM-1 expression and metastasis（rs=0. 571, P=0. 000）,but there were not relationship with clinical staging, T staging, age and gender （P 〉 0.05）. Conclusion： The abnormal expression of ELAM-1 can be helpful for prognosis of NPC, but it has no correlation with clinical parameters.