吸烟对术前TPF诱导化疗的口腔鳞癌患者术后切口愈合的影响研究

THE INFLUENCE OF SMOKING AND PREOPERATIVE TPF INDUCED CHEMOTHERAPY ON WOUND HEALING OF ORAL SQUAMOUS CARCINMA PATIENTS AFTER SURGERY

目的:探讨吸烟对术前TPF诱导化疗的口腔鳞癌患者术后切口愈合的影响。方法:选择21例接受术前TPF诱导化疗的口腔鳞癌患者作为研究对象,根据患者吸烟与否分为吸烟组和非吸烟组,观察术后14d内切口缩小率、切口炎性反应及渗出量、术后VAS疼痛评分情况。结果:术后7,14d,吸烟组术后切口愈合速度比非吸烟组慢(P<0.05),而切口炎性反应重(P<0.05),切口渗出量多(P<0.05),术后VAS疼痛评分大于非吸烟组(P<0.05)。结论:吸烟对术前TPF诱导化疗的口腔鳞癌患者术后切口的愈合速度有影响。

Objective. To analyze the effects of smokingand preoperative TPF induced chemotherapy on the wound healing of oral squamous carcinoma patients treated with operation. Methods. Twenty-one oral squamous carcinoma patients treated with TPF induced chemotherapy before surgery were enrolled into this study and divided into smoking group and non-smoking group. When patients were received operation after 14 days, their wound area reduced rate, inflammatory reaction, efflusion amount, pain analysis respectively were evaluated. Results： In the 7^th day and 14^th day after operation, the speed of wound healing , inflammatory reaction, efflusion amount and the pain sore in no smoking group were better than that in smoking group （ P 〈0. 05）. Conclusion： Smoking can reduce wound healing rate in oral squamous carcinoma pa-tients treated with TPF induced chemotherapy before surgery.