106株急性阑尾炎病原菌耐药性分析及抗菌药物的合理使用

The analysis of drug resistance and rational use of antimicrobial agents in 106 cases of acute appendicitis

目的分析急性阑尾炎感染病原菌的耐药情况。方法选取该院普外科2013年1～6月急性阑尾炎患者标本的病原菌分离情况及药敏特性进行分析。结果分离病原菌106株，其中革兰阴性菌100株，占94．34％（大肠埃希菌、肺炎克雷伯杆菌和铜绿假单孢菌分别占67．92％、11．32％、5．66％），革兰阴性菌对哌拉西林、环丙沙星、庆大霉素、左氧氟沙星、妥布霉素和头孢吡肟的耐药率高，对哌拉西林他唑巴坦、头孢西丁和亚胺培南的耐药率低。结论急性阑尾炎感染细菌的耐药率高。

Objective To study the drug resistance of infection bacteria deriving from acute appendicitis patients. Methods The separation and the drug sensitive characteristic of bacteria deriving from the specimen of acute appendicitis patients were ana- lyzed,who were admitted in the general department of our hospital from January to June 2013. Results One hundred and six bacteria strains were isolated. Among them, 100 （94： 34%） strains were Gram negative bacteria strains,including escherichia coli, klebsiella pneumonia bacillus and verdigris fake single spore bacterium,in a proportion of 67.92 %, 11.32% and 5.66% respectively. The resistance of piperacillin, ciprofioxacin, gentamycin, levofloxacin, tobramycin and eefepime was high in Gram negative bacteria, while the lower resistance to piperacillin / tazobactam,cefoxitin and imipenem. Conclusion The resistant rate of acute appendicitis infection bacteria is high.