10例经导管肾动脉交感神经射频消融术治疗顽固性高血压

Clinical effect of 10 patients with resistant hypertension treated by transcatheter renal sympathetic denervation

目的探讨经导管肾动脉交感神经射频消融术(RDN)治疗顽固性高血压的临床疗效。方法回顾性分析10例经RDN治疗的顽固性高血压患者的临床资料,分析RDN治疗后患者血压的变化及并发症情况。结果患者术后2周收缩压、舒张压均较术前明显下降,术后3个月进一步下降,差异均有统计学意义(P<0.05),术后6个月与术后3个月比较差异无统计学意义(P>0.05);术前平均应用降压药种数为(5.3±0.9)种,术后6个月随诊平均用药种类(3.2±0.6)种,较术前明显减少,差异有统计学意义(P<0.05)。患者未出现不良反应。结论 RDN可迅速、持续地降低顽固性高血压患者的血压水平,具有较好的安全性。

Objective To evaluate the clinical efficacy of transcatheter renal sympathetic denervation（RDN） in the treatment of resistant hypertension. Methods Clinical data of 10 patients with resistant hypertension treated by transcatheter renal sympa- thetic denervation were retrospectively analyzed. The blood pressure and complications were analyzed. Results In all of the 10 patients,systolic and diastolic blood pressure decreased significantly after two weeks compared with preoperative, and further de creased after 3 months （P〈0.05）. There were no statistical difference of systolic and diastolic blood pressure between 3 and 6 months（P〈0.05）. Before the RDN,the mean number of antihypertensive drugs was 5.3±0.9. After 6 months which was 3.2±0. 6, and which was decreased significantly compared with the preoperative （P〈0.05）. No adverse reactions were found. Conclusion The RDN can be quickly and sustained decrease the blood pressure in patients with resistant hypertension.