支气管动脉灌注化疗对中央型非小细胞肺癌伴阻塞性肺炎的疗效观察

Clinical observation on the bronchial artery infusion in the treatment of central NSCLC with obstructive pneumonia

目的通过对支气管动脉灌注化疗(BAI)治疗中央型非小细胞肺癌伴阻塞性肺炎疗效观察,了解影响疗效的临床因素。方法采用回顾性分析方法,收集经病理学确诊的64例中央型非小细胞肺癌伴阻塞性肺炎患者作为研究对象。观察单纯静脉使用抗菌药物的对照组与加用BAI的治疗组的疗效,以及治疗组中既往曾行标准的全身静脉化疗/放疗的复治组与未行任何放化疗的初治组之间疗效情况。结果对照组阻塞性肺炎治愈好转率为43.33%。而治疗组阻塞性肺炎治愈好转率为70.59%。在治疗组中,复治组患者阻塞性肺炎治愈好转率为50.00%;而初治组患者阻塞性肺炎治愈好转率为88.89%。结论中央型非小细胞肺癌伴阻塞性肺炎在全身静脉使用抗菌药物的基础上,加用BAI治疗,可明显提高阻塞性肺炎治愈好转率。

Objective To observe the effect of bronchial artery infusion chemotherapy in the treatment of central non-small ceil lung cancer （central NSCLC） with obstructive pneumonia and its efficacy clinical factors. Methods Retrospective analysis method was applied to the 64 cases of central NSCLC with obstructive pneumonia. All patients were confirmed by pathology. We main contrasted the efficacy between intravenous infusion of antimicrobial agents and bronchial artery infusion chemotherapy （BAI）. we focused on the efficacy between treatment group using standard systemic vein chemotherapy/radiotherapy and primary group with no chemotherapy/radiotherapy. Results In control group,the improvement rate was 43.33%. The improvement rate in treatment group was 70.59%. In treatment group,the curing rate was 50.00% for the patients who had ever taken standard sys- temic chemotherapy/radiotheraPy. But the curing rate was 88.890% for the primary group. Conclusion For the patients who have the central NSCLC with obstructive pneumonia,intravenous infusion of antimicrohial agents and bronchial artery infusion chemo- therapy （BAD can obviously increase the curing rate of obstructive pneumonia.