非小细胞肺癌患者中期因子与D-二聚体水平的相关性研究

STUDY ON THE CORRELATION BETWEEN MIDKINE AND D-DIMER LEVEL IN PATIENTS WITH NON-SMALL CELL LUNG CANCER

目的:分析非小细胞肺癌患者血清中期因子(MK)和血浆D-二聚体水平的相关性。方法:分别检测52例非小细胞肺癌患者和52例健康对照者血清中期因子水平和血浆D-二聚体水平,并分析非小细胞肺癌患者中期因子水平和血浆D-二聚体水平的相关性。结果:非小细胞肺癌组患者中期因子水平和D-二聚体水平均明显高于健康对照组(P<0.05);并且,非小细胞肺癌中期因子水平和D-二聚体水平与肿瘤TNM分期有关(P<0.05),与肿瘤的病理类型无关(P>0.05)。非小细胞肺癌患者中期因子水平与D-二聚体水平呈正相关关系(r=0.683,P<0.05)。结论:中期因子和D-二聚体可能在非小细胞肺癌的发生发展过程中具有协同作用。

Objective： To analyze the correlation between serum midkine（MK） and plasma D-dimer level in patients with non-small cell lung cancer. Methods： The serum midkine level and plasma D-dimer level of 52 non-small cell lung cancer patients and 52 healthy controls were respectively detected and analyzed their correlation. Results： The serum midkine level and plasma D-dimer level of non-small cell lung cancer patients were obviously higher than that of healthy controls（P 〈0.05）. The midkine and D-dimer level were related to TNM stage（P 〈0.05）, but unrelated to pathological type（P 〈0.05）. For non-small cell lung cancer patients, the midkine level was positively correlated to D-dimer level（r=0.683, P 〈0.05）. Conclusions： Midkine and D-dimer may have synergistic effects in development of non-small cell lung cancer.