Q-Tcd对乳腺癌表阿霉素化疗致心肌损伤的早期预测价值

EARLY PREDICTION VALUE OF Q-T INTERVAL DISPERSION FOR MYOCARDIAL INJURY INDUCED BY EPIRUBICIN IN BREAST CANCER PATIENTS

目的:探讨Q-T间期离散度(Q-Tcd)预测表阿霉素导致早期心肌损伤的应用价值。方法:44例乳腺癌患者均采用含表阿霉素的方案化疗,使用剂量为75mg/m2,治疗1-5个周期。根据肌钙蛋白Ⅰ水平将患者分为心肌损伤组和未发生心肌损伤组,比较患者的Q-T间期离散度和心脏超声结果。结果:44例患者中心肌损伤组16例、未发生心肌损伤组28例。心肌损伤组患者Q-T间期离散度明显高于未发生心肌损伤组(P<0.05);两组心脏超声左室舒张末期前后径、左室射血分数比较差异无统计学意义(P>0.05)。结论:表阿霉素对心肌损伤的评价指标中,Q-T间期离散度较左室舒张末期前后径和射血分数更为敏感,对表阿霉素致心肌病具有预测价值。

Objective： To investigate the predictive value of Q-T interval dispersion（Q-Tcd） for early myocardial injury induced by epirubicin. Methods： 44 breast cancer patients were all treated with epirubicin for 1-5 cycles with the dose was 75mg/m2. The patients were divided into myocardial injury group and non-myocardial injury group according to the troponinⅠ level; The Q-T interval dispersion and echocardiographic results of patients in 2 groups were compared. Results： 44 breast cancer patients, myocardial injury group had 16 patients, non- myocardial injury group had 28 patients. The Q-T interval dispersion of patients in myocardial injury group was obviously higher than that of patients in non- myocardial injury group（P 〈0.05）. There had no statistical signif icance about left ventricular end diastolic diameter and left ventricular ejection fraction of patients in 2 groups（P〉 0.05）. Conclusions： Compared with left ventricular end diastolic diameter and left ventricular ejection fraction, Q-T interval dispersion is more sensitive for forecasting early myocardial injury induced by epirubicin.