不同时相球囊导管静脉取栓的研究

Removal of venous thrombus by Fogarty ballon catheter at different time

目的 探讨静脉血栓形成后不同时相静脉血管壁胶原含量的变化 ,以及应用Fogarty球囊导管取栓对静脉血管壁影响。方法 测量大鼠下腔静脉血栓形成模型静脉壁中的胶原含量。血栓形成后 ,观察不同时相应用Fogarty球囊导管取栓对静脉血管壁的损伤情况。 结果 静脉壁外膜出现胶原沉积 ,胶原量在静脉血栓形成后第 10d达到最高峰 ,与对照组比较差异有显著性 (P <0 .0 5 )。不同时相应用Fogarty球囊导管取栓后 ,静脉壁内皮细胞脱落的数量、静脉血管壁损伤的深度均差异有显著性(P <0 .0 5 )。结论 应用Fogarty球囊导管进行静脉血栓取栓治疗的时机以静脉血管壁结构未发生改变 ,血栓出现机化前为好。

Objective To determine the collagen deposition in adventitia of venous wall and the influence of removal venous thrombus by Fogarty balloon catheter on venous wall at different time.Methods The collagen deposition in adventitia of venous wall in inferior vena caval thrombosis in rats, and the injury of venous wall caused by Fogarty balloon catheter removal of thrombus at different time were observed. Results Collagen deposition in adventitia of venous wall increased with time. The peak of collagen deposition was 10 days after thrombus formation, which was significantly different from the control group (P<0.05). After thrombus was removed by Fogarty balloon catheter at different time, the number of endothelial denudation and the depth of injury of venous wall were significantly different (P<0.05) before and after the thrombus organization. Conclusions The best timing of thrombectomy by Fogarty balloon catheter is before the change of venous wall and venous thrombosis being organized.