中西医结合治疗糖尿病肾病临床研究

Clinical Study on Treatment of Diabetic Nephropathy with Combination of TCM and Western Medicine

目的:观察中西医结合治疗糖尿病肾病的临床疗效。方法:92例糖尿病肾病患者随机分为试验组48例和对照组44例。对照组采用常规疗法,试验组在对照组的治疗基础上加用益肾活血的中药。比较两组临床疗效,尿微量白蛋白(urine micro UMBumin,UMB)/尿肌酐(urine creatinine,UCr)、24小时尿蛋白定量、血肌酐(serum creatinine,SCr)、血尿素氮(blood urea nitrogen,BUN)及空腹血糖和餐后血糖。结果:治疗后,试验组有效率为94.8%,对照组有效率为82.8%,两组有效率比较,差异有统计学意义(P<0.05)。两组24小时尿蛋白定量、SCr、BUN等较治疗前均有所下降,但试验组下降程度更明显;试验组UMB/UCr高于对照组(P<0.05)。试验组空腹血糖和餐后血糖分别为(6.57±1.38)mmol·L-1和(8.00±1.38)mmol·L-1;对照组空腹血糖和餐后血糖分别为(7.67±2.38)mmol·L-1和(8.80±1.45)mmol·L-1,两组比较,差异有统计学意义(P<0.05)。结论:中西医结合治疗糖尿病肾病疗效显著,可明显改善患者临床症状。

Objective ： To observe the clinical effect of combined traditional Chinese and Western medicine treatment of diabetic nephrop- athy. Methods：92 cases of diabetic nephropathy patients were randomly divided into experimental group（ n = 48 ） and control group（ n = 44）. The control group was treated with conventional therapy and the experimental group was given Chinese medicine therapy. Compare the clinical efficacy, urinary microalbumin（ urine microUMBumin, UMB） urinary creatinine urine creatinine （UCR） ,24 hours urine pro- tein quantitation, serum creatinine, serum creatinine, SCR） and blood urea nitrogen and blood urea nitrogen （BUN） and fasting and postprandial blood glucose. Results：After treatment, the efficiency was 94.8% in test group and 82.8% in the control group. Compared the efficient of two groups, the difference was statistically significant （ P 〈 0.05 ）. The 24 hours urine protein, SCR, bun of Two groups were decreased, but the test group decreased more significantly;the UMB/UCR of experimental group was higher than those in control group（ P 〈 0.05 ）. The fasting blood glucose and postprandial blood glucose of test group were respectively（6.57 ± 1.38 ） mmol · L-1 and （8. 00 ± 1.38） mmol·L- 1. The fasting and 2H blood glucose of control group were （7.67 ±2.38） mmol · L- 1 and （8.80 ± 1.45 ） mmol · L - 1. Compared of two groups, the difference was statistically significant （ P 〈 0.05 ）. Conclusion ： The combination of tra- ditional Chinese and western medicine treatment of diabetic nephropathy has obvious curative effect and can significantly improve the clinical symptoms of the patients.