摘要
糖基化终产物(advanced glycation-end products,AGEs)是在持续高糖状态下,蛋白质的氨基与糖的醛基在非酶催化反应下生成的终产物,与糖尿病慢性并发症的发生发展密切相关。AGEs可以导致多种眼部疾病发生,如糖尿病性白内障、糖尿病视网膜病变、黄斑病变及青光眼等。本文就AGEs的生成及其参与糖尿病相关眼病的可能作用机制进行综述。
Advanced glycation-end products （AGEs） are the final products produced in the non-enzymatic catalysis reaction in the condition of continuous glucose, and play a critical role in the progression of chronic complications in diabetic mellitus. AGEs have been implicated in vision loss associated with diabetic cataract, diabetic retinopathy, macular degeneration and glaucoma. This article reviews recent research about the formation of AGEs and the correlation between eye diabetic diseases and AGEs.
出处
《眼科新进展》
CAS
北大核心
2015年第8期787-790,共4页
Recent Advances in Ophthalmology
基金
国家自然科学基金资助(编号:81070720)~~
