以NPC1L1为靶点治疗胆固醇结石的研究进展

Recent progress in targeting Niemann-Pick C1L1 protein for cholesterol gallstone therapy

胆固醇结石病因形成复杂,涉及到胆汁脂类分泌的改变、胆固醇结晶、胆囊组织中的重要免疫反应、粘蛋白的形成以及胆囊动力不足等多个方面。抑制肠道对胆固醇的吸收、减少胆汁分泌是胆固醇结石的治疗策略之一。尼曼-匹克C1型类似蛋白1(NPC1L1)的表达水平对胆固醇结石的发生具有双重作用。本文综述以NPC1L1蛋白为靶点治疗胆固醇结石的研究进展。

The etiology of cholesterol gallstone is complexed which includes changing of biliary lipid secretion,cholesterol crystal,immune reaction in the tissues of gallbladder,formation of mucin,defection of gallbladder motility and so on. One of the therapeutic approaches to cholesterol gallstones is reducing bile secretion and absorption of cholesterol in intestinal. The expression level of Niemann- Pick C1 Like 1（ NPC1L1） has a dual role to the incidence of cholesterol gallstones. In this paper,we reviewed the progress of targeting NPC1L1 protein as a treatment of cholesterol gallstones.